Intraoperative Unfractionated Heparin Unresponsiveness During Endovascular Repair of a Ruptured Abdominal Aortic Aneurysm Following Administration of Andexanet Alfa for the Reversal of Rivaroxaban

ConclusionThis case highlights the potential complications of using UFH anticoagulation following reversal of factor Xa inhibitors with andexanet alfa and underscores the importance of peri ‐procedural anticoagulation planning. For patients who require intra‐operative anticoagulation, providers should consider anticoagulation reversal with prothrombin complex concentrate instead of andexanet alfa or administration of a parenteral direct thrombin inhibitor, such as argatroban or bi valirudin during the surgical procedure.This article is protected by copyright. All rights reserved.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Case Report Source Type: research

Related Links:

This article reviews the PMCT and PMCTA techniques in terms of their indications, applications, advantages, and limitations for cardiothoracic applications. Our findings will enhance readers’ understanding of emerging CT techniques in forensic radiology.
Source: Journal of Thoracic Imaging - Category: Radiology Tags: Review Articles Source Type: research
Lung transplantation is an established therapeutic option for patients with irreversible end-stage pulmonary disease limiting life expectancy and quality of life. Common indications for lung transplantation include chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cystic fibrosis, pulmonary arterial hypertension, and alpha-1 antitrypsin deficiency. Complications of lung transplantation can be broadly divided etiologically into surgical, infectious, immunologic, or neoplastic. Moreover, specific complications often occur within a certain time interval following surgery, which can be broadly classified as...
Source: Journal of Thoracic Imaging - Category: Radiology Tags: Review Articles Source Type: research
Conclusions: 3D semiautomatic quantification of PPV is feasible and reproducible using CT in patients with occupational exposure to asbestos. PPV measurement may be useful to correlate with other asbestos-related disease outcomes and prognosis.
Source: Journal of Thoracic Imaging - Category: Radiology Tags: Original Articles Source Type: research
Purpose: A common diagnostic dilemma in the assessment of small pulmonary nodules on computed tomography (CT) is in distinguishing benign intrapulmonary lymph nodes (IPLNs) from small primary pulmonary malignancies. Several CT features have been described of IPLNs, including attachment to a pleural surface. We had observed that IPLNs were often connected to a pulmonary vein and sought to evaluate the utility of this sign in discriminating IPLNs from lung adenocarcinomas. The frequency of other previously described CT signs of IPLNs was also compared with lung adenocarcinomas. Materials and Methods: We retrospectively ...
Source: Journal of Thoracic Imaging - Category: Radiology Tags: Original Articles Source Type: research
Abstract OBJECTIVE/BACKGROUND: Epidural analgesia improves pain control and outcomes of abdominal aortic aneurysm procedures, while the effect of thoracic epidural analgesia on thoraco-abdominal aortic aneurysm (TAAA) repair is unknown. The aim of the study was to evaluate thoracic epidural analgesia effects in patients undergoing open TAAA repair in terms of pain control and clinically relevant outcomes. METHODS: This was a retrospective study of a prospectively collected database. Patients undergoing open TAAA repair between January 2009 and December 2016. RESULTS: Four hundred and fifty-nine consecuti...
Source: PubMed: Eur J Vasc Endovasc ... - Category: Surgery Authors: Tags: Eur J Vasc Endovasc Surg Source Type: research
In this study, cangrelor was discontinued 1-6 hours prior to surgery, while aspirin was continued throughout the perioperative period. Bridging with cangrelor did not increase major bleeds prior to surgery, though minor bleeds, mostly ecchymosis at venipuncture site, was higher. P2Y12 assay documented sufficient platelet inhibition corresponding to levels required for anti thrombotic effect [1]. Cangrelor is awaiting approval and more large scale trials regarding the use of bridging are needed. Reference 1. Angiolillo DJ et al; BRIDGE Investigators. Bridging antiplatelet therapy with cangrelor in patients undergoing ...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
An active man in his early 80s presented to the hospital with a 6-month history of cramping epigastric abdominal pain that occurred 30 minutes after eating solid food and was associated with nausea and vomiting. His medical history was significant for atrial fibrillation and a history of an open abdominal aortic aneurysm repair. What is your diagnosis?
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
A 72-YEAR-OLD, 99-kg, 170-cm man was transferred to the authors’ institution from a community hospital for evaluation of new, severe, stabbing chest pain radiating to his back. The patient’s pain began suddenly at his home and was accompanied by dizziness, palpitations, diaphoresis, dyspnea, and nausea. He acknowledged a history of coronary artery disease and stated that he previously underwent coronary stent implantation more than a decade before the current admission. His past medical history was notable for chronic atrial fibrillation, hypertension, hyperlipidemia, tobacco use, and an abdominal aortic aneury...
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Diagnostic Dilemma Source Type: research
A 68-year-old man was admitted to our clinic with abdominal pain. In his medical history, he has had chronic atrial fibrillation for 5 years and aortic valve replacement were applied 4 years ago. On physical examination, arterial blood pressure was 120/70 mmHg and peripheral pulses were weak in both lower limbs. The abdominal aortic aneurysm was detected on examination. Electrocardiography and transthoracic echocardiography were in normal limits. In abdominal computed tomography angiography, a aortic aneurysm, 2.5 cm below the left renal artery orifice extending to the aortic bifurcation, approximately 49x54 mm i...
Source: The American Journal of Cardiology - Category: Cardiology Authors: Tags: Poster Abstract Source Type: research
More News: Abdominal Aneurysm Repair | Abdominal Aortic Aneurysm | Angiography | Aortic Aneurysm | Atrial Fibrillation | CT Scan | Drugs & Pharmacology | Endovascular Repair (EVAR) | Gastroschisis Repair | Pain