Intraoperative Unfractionated Heparin Unresponsiveness During Endovascular Repair of a Ruptured Abdominal Aortic Aneurysm Following Administration of Andexanet Alfa for the Reversal of Rivaroxaban

ConclusionThis case highlights the potential complications of using UFH anticoagulation following reversal of factor Xa inhibitors with andexanet alfa and underscores the importance of peri ‐procedural anticoagulation planning. For patients who require intra‐operative anticoagulation, providers should consider anticoagulation reversal with prothrombin complex concentrate instead of andexanet alfa or administration of a parenteral direct thrombin inhibitor, such as argatroban or bi valirudin during the surgical procedure.This article is protected by copyright. All rights reserved.

Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - June 27, 2019 Category: Drugs & Pharmacology Authors: Ifeoma Mary Eche, Pansy Elsamadisi, Nicole Wex, Mark Wyers, Gabriel A. Brat, Katherine Cunningham, Kenneth A. Bauer Tags: Case Report Source Type: research