MEK Inhibition Induces Therapeutic Iodine Uptake in a Murine Model of Anaplastic Thyroid Cancer

Conclusion: This study confirms the ability of MEK inhibition to induce iodine uptake in in vitro and in vivo models of ATC. The approach of using a MEK inhibitor before radioiodine treatment could readily be translated into clinical practice and provide a much-needed therapeutic option for patients with ATC.

Source: Journal of Nuclear Medicine - June 30, 2019 Category: Nuclear Medicine Authors: ElMokh, O., Taelman, V., Radojewski, P., Roelli, M. A., Stoss, A., Dumont, R. A., Dettmer, M. S., Phillips, W. A., Walter, M. A., Charles, R.-P. Tags: Basic Source Type: research