Validating the inhibitory effects of d - and l -serine on the enzyme activity of d -3-phosphoglycerate dehydrogenases that are purified from Pseudomonas aeruginosa , Escherichia coli and human colon

ConclusionsThese results suggest thatl-serine significantly repressedP. aeruginosa pathogenicity through direct inhibition of the PGDH activity, but was not able to inhibit the human PGDH activity. Oral administration ofl-serine to compromised hosts might interfere with bacterial translocation and prevent gut-derived sepsis caused byP. aeruginosa through inhibition of the function of theserA gene product.
Source: Gut Pathogens - Category: Microbiology Source Type: research