Vitamin B12 deficiency anemia in an exclusively breastfed infant born to an ileum-resected mother

Vitamin B12 (cobalamin) is essential for folate metabolism and DNA synthesis. It acts as a cofactor for two key enzymatic reactions, methylation of homocysteine to methionine and conversion of methylmalonyl coenzyme A (CoA) to succinyl CoA.1 Deficiency of vitamin B12 results in an accumulation of homocysteine and methylmalonic acid, resulting in hematologic and neurologic manifestations.1 Although vitamin B12 deficiency is rare in developed countries, it is important to recognize this condition because early treatment can prevent potentially devastating neurologic sequelae.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Short Communication Source Type: research

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Abstract Vitamin B6 (VB6) deficiency contributes to oncogenesis and tumor progression in certain cancers, and is prevalent in cancer patients in general. VB6 is also an essential element of heme synthesis, and deficiency can lead to anemia. Primary myelofibrosis (PMF) and secondary myelofibrosis (sMF) are myeloproliferative neoplasms often presenting with anemia along with other cytopenias. We performed a prospective study to determine whether PMF and sMF patients suffer from VB6 deficiency, and whether VB6-deficient patients show improvement of anemias with VB6 supplementation. Twelve PMF patients and 11 sMF pati...
Source: International Journal of Hematology - Category: Hematology Authors: Tags: Int J Hematol Source Type: research
VITAMIN B12 deficiency is a common condition that could manifest to neurological and even psychiatric disorders. A worrying cause of the vitamin deficiency could cause pernicious anaemia. These are the five warning signs you could be developing the condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Abstract Approximately 14-40% of patients in industrialized countries present with preoperative anemia. Depending on the severity, anemia is associates with increased perioperative morbidity and mortality. One of the most important causes of preoperative anemia is iron deficiency which is usually easy to treat. Implemented in the multimodal concept of patient blood management, the diagnostics and treatment of preoperative anemia are important aspects for improvement of perioperative outcome. Adequate and early diagnostics of the cause of anemia before treatment is important because treatment options, e.g. with iro...
Source: Der Anaesthesist - Category: Anesthesiology Authors: Tags: Anaesthesist Source Type: research
Very commonly, no cause for iron deficiency and iron deficiency anemia are found: no gastrointestinal bleeding, no excessive menstrual blood loss, no hemolysis (red blood cell destruction). Your doctor tells you that there is no identifiable cause and you are therefore resigned to taking iron supplements, prescription iron, injectable iron, or even blood transfusions while the anemia often does not respond or does so only temporarily. Here are two situations in which iron deficiency develops that are rarely addressed by doctors, but YOU can: The phytates of wheat and grains—Modern wheat, in particular, has been se...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Iron deficiency anemia minerals phytates wheat belly Source Type: blogs
This study evaluated whether high-titer (GPCA titer ≥ 160) GPCA+AG patients had greater frequencies of anemia, vitamin B12 deficiency, macrocytosis, and hyperhomocysteinemia than low-titer (GPCA titer 
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
ConclusionIn the juvenile population, ATD and AIG may also be associated. PCA screening is useful to detect subjects at risk for this condition. Due to the longer life expectancy of the pediatric population and considering the relatively high risk of malignant transformation, early surveillance monitoring is mandatory for children and adolescents with ATD.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
We report a 5-month old exclusively breastfed full-term infant with emesis, lethargy, progressive pancytopenia, hemolysis, hypofibrinogenemia, elevated lactate dehydrogenase and a hypercellular bone marrow with dyserythropoiesis. The B12 level in the serum was undetectable. The infant’s lethargy resolved within 48 hours of intramuscular B12 injection, followed by rapid improvement of pancytopenia. The asymptomatic mother had a normal hemoglobin and mean corpuscular volume, but undetectable B12 level and positive antibodies to intrinsic factor, consistent with pernicious anemia masked by folate supplementation in the ...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research
Listen to critics of the Wheat Belly lifestyle and you’d think that, by banishing all things wheat and grains from your life, you will be excommunicated from your church, tossed out of your club, ostracized by friends and family, and suffer dire health consequences like heart disease and colon cancer. After all, they say that you are eliminating an entire food group and will be crippled by lack of fiber and nutrients. Worse, our focus on increasing our intake of fats and oils will get you a heart attack, three stents, or bypass surgery and you’ll be obliged to take Lipitor and Repatha for a lifetime. First of a...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle grain-free Weight Loss Source Type: blogs
ConclusionsWith or without malnutrition, iron deficiency anemia, vitamin B12 deficiency and vitamin D deficiency were common in the home care elderly patients.
Source: The Journal of Nutrition, Health and Aging - Category: Nutrition Source Type: research
Abstract In 1998 a Tolerable Upper Intake Level (UL) for folic acid was established based on case reports from the 1940s suggesting that high-dosage folic acid intake, used to treat patients with pernicious anemia, had the potential to precipitate or speed-up the development of neurological problems. This UL has been employed in the decision-making process used by more than 80 countries to establish programs to fortify staple foods with folic acid to prevent neural tube birth defects. Some have claimed that this UL is flawed and has become an obstacle to the wider adoption of neural tube defect prevention programs...
Source: The American Journal of Clinical Nutrition - Category: Nutrition Authors: Tags: Am J Clin Nutr Source Type: research
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