Histocompatibility: minor differences have a major impact

Nature Reviews Nephrology, Published online: 28 June 2019; doi:10.1038/s41581-019-0175-yThe clinical relevance of minor histocompatibility antigens in transplantation is disputed. High-throughput approaches are now being used to investigate the role of genome-wide genetic incompatibility in transplant outcomes. A recent study reports that donor and recipient mismatch at the LIMS1 locus is associated with an increased risk of acute rejection.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research