The therapeutic potential of mesenchymal stem cells in lung cancer: benefits, risks and challenges

ConclusionsHere, we present published data on the cell- and secretome-based therapeutic competences of MSCs, as well as on their potential as engineered delivery vectors for the treatment of lung cancer. Despite the controversial role of MSCs in the context of lung cancer therapy, current findings support hopeful perspectives to harness the potential of MSC-based regimens that may augment current treatment modalities in lung cancer.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research

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Abstract An important harmonization effort was produced by the scientific community to standardize both the preanalytical and interpretative phases of programmed death-ligand 1 (PD-L1) immunohistochemical (IHC) testing in non-small-cell lung cancer (NSCLC). This analysis is crucial for the selection of patients with advanced-stage tumors eligible for treatment with pembrolizumab and potentially with other anti-PD-1/PD-L1 checkpoint inhibitors. This multicentric retrospective study evaluated the reproducibility of PD-L1 testing in the Italian scenario both for closed and open platforms. In the evaluation of the wel...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Authors: Zeng T, Qin Q, Bian Z, Li J Abstract Aims: The present study was performed to investigate the efficacy and safety of anti-programmed death-1 (PD-1)/programmed death-ligand-1 (PD-L1) treatments in non-small cell lung cancer (NSCLC).Methods: The potential articles were searched from Pubmed and Embase. The end points included overall survival (OS), progression-free survival (PFS), objective response rate (ORR) and adverse events. p 
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Approximately 27% of completed lung cancer trials were unpublished as of 2016, raising concern about publication bias, a cross-sectional study suggests.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
ConclusionThis study includes preliminary clinical data of SCLC patients with bone metastases at the time of diagnosis, and more studies are needed.
Source: Journal of Bone Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: Antimony carcinogenicity evidence involving workers is inadequate, based on confounding, small sample sizes, incomparability across studies, and inadequate reference populations. An increased lung cancer risk cannot be excluded. Evidence for lung neoplasms caused by antimony trioxide inhalation in experimental animals is sufficient. Overall, carcinogenicity in workers is probable (International Agency for Research on Cancer (IARC) 2A). It remains unclear from what occupational exposure duration and dose this effect arises and whether exposure threshold values should be reconsidered.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
In this study, we discovered that miR-561 expression was downregulated in human NSCLC tissues and cell lines. The overexpression of miR-561 inhibited NSCLC cell proliferation and cell cycle G1-S transition and induced apoptosis. The inhibition of miR-561 facilitated cell proliferation and G1-S transition and suppressed apoptosis. MiR-561 expression was inversely correlated with P-REX2a expression in NSCLC tissues. P-REX2a was confirmed to be a direct target of miR-561 by using a luciferase reporter assay. The overexpression of miR-561 decreased P-REX2a expression, and the suppression of miR-561 increased P-REX2a expression...
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research
There are positive trends, including the survival numbers: Compared with a decade ago, the five-year survival rate among lung cancer patients was 26% higher in 2015.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Considerable variation found between states in five - year survival, treatment, early diagnosis, screening
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Family Medicine, Internal Medicine, Oncology, Pulmonology, Radiology, Institutional, Source Type: news
AbstractLung cancer is a leading cause of cancer death in Latinos. In a telephone survey, we assessed perceptions about lung cancer and awareness of, interest in, and barriers to lung screening among older current and former smokers. We compared Latino and non-Latino responses adjusting for age, sex, education, and smoking status using logistic regression models. Of the 460 patients who completed the survey (51.5% response rate), 58.0% were women, 49.3% former smokers, 15.7% Latino, with mean age 63.6  years. More Latinos believed that lung cancer could be prevented compared to non-Latinos (74.6% vs. 48.2%, OR 3.07, C...
Source: Journal of Immigrant and Minority Health - Category: International Medicine & Public Health Source Type: research
Authors: Gulak MA, Bornais C, Shin S, Murphy L, Smylie J, Pantarotto JR, Fung-Kee-Fung M, Maziak DE Abstract Background: Patients with lung cancer often experience stressful delays throughout the diagnostic phase of care. To address that situation, our multidisciplinary team created a "Navigation Day," during which patients partake in a single-day visit that comprises nurse-led teaching, social work, smoking cessation counselling, symptom control, and dedicated test slots for integrated positron-emission tomography and computed tomography (pet/ct), pulmonary function tests (pfts), and magnetic resonance i...
Source: Current Oncology - Category: Cancer & Oncology Tags: Curr Oncol Source Type: research
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