Heberprot-P's Effect on Gene Expression in Healing Diabetic Foot Ulcers.

CONCLUSIONS Our findings suggest that Heberprot-P's healing action on diabetic foot ulcers is mediated through changes in genetic expression that reduce hypoxia, inflammation and oxidative stress, and at the same time increase cell proliferation, collagen synthesis and extracellular matrix remodeling. The kinetics of expression of two genes related to extracellular matrix formation needs further exploration. KEYWORDS Epidermal growth factor, EGF, diabetic foot ulcer, wound healing, quantitative real-time PCR, gene expression, Cuba. PMID: 31242156 [PubMed - in process]
Source: MEDICC Review - Category: International Medicine & Public Health Tags: MEDICC Rev Source Type: research

Related Links:

CONCLUSIONS: Although both metformin and BM-MSCs were effective in the healing of experimentally induced skin wounds in diabetic rats, the combination of both agents appears to be a better synergistic option for the treatment of diabetic wound injuries. PMID: 31489604 [PubMed - as supplied by publisher]
Source: Folia Histochemica et Cytobiologica - Category: Cytology Tags: Folia Histochem Cytobiol Source Type: research
CONCLUSIONSeverely anemic patients in critical condition can survive necrotizing fasciitis with a well-planned interdisciplinary approach without compromising patient autonomy.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
CONCLUSIONS: These results showed length of surgery and intraoperative blood loss were independent risk factors for PU after liver resection with a long surgical duration. Use of PU prevention strategies are recommended for patients who undergo liver resection with massive intraoperative blood loss and long surgical duration. PMID: 31461399 [PubMed - in process]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
Purpose of review The current review addresses one of the most common neurological disorders, diabetic polyneuropathy (DPN). DPN is debilitating, irreversible and dwarfs the prevalence of most other chronic disorders of the nervous system. Its complications include foot ulceration, amputation, falling and intractable neuropathic pain. Moreover, tight control of hyperglycemia reduces the incidence of DPN in type 1 diabetes mellitus but its role in type 2 diabetes mellitus is less clear. Recent findings New therapeutic options to reverse the development of DPN or its associated pain have been proposed but none have sign...
Source: Current Opinion in Neurology - Category: Neurology Tags: PERIPHERAL NERVE AND NEURO-MUSCULAR JUNCTION DISEASE: Edited by Mary M. Reilly Source Type: research
This study addresses principal aspects in the prevention of DFUs. First, the sensor-equipped insole will be evaluated for daily performance in home-based measurements of foot temperatures. Second, a telemedicine structure is tested that evaluates sensor data automatically and proposes suitable intervention measures under the supervision of a physician. Third, predictive models for DFUs will be built using the collected sensor data allowing for interpretations, which in the future may support medical care providers.Trial registrationGerman Clinical Trials Register (DRKS),DRKS00013798. Registered on 18 January 2018.
Source: Trials - Category: Research Source Type: clinical trials
Introduction: Necrolytic migratory erythema (NME) may correspond to a paraneoplastic syndrome. It usually occurs in patients with glucagonoma, an alpha cell pancreatic tumor. When associated with weight loss, angular stomatitis, glossitis, diabetes mellitus, anemia and neuropsychiatric disorders defines the glucagonoma syndrome. NME lesions present as erythematous maculopapules with blisters and ulceration, occurring mostly on perineum, lower abdomen, extremities and face.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
A 98-year-old woman with longstanding cardiovascular disease and noninsulin-dependent diabetes mellitus was admitted to the hospital for evaluation of a chronic, nonhealing, postauricular ulceration. History revealed an episode of right-sided unilateral tinnitus approximately two years prior prompting otolaryngology evaluation and external auditory canal debridement. Within weeks of the procedure, a small, pruritic, hypoalgesic ulcer developed over the right posterolateral scalp which rapidly expanded in size over the proceeding months before eventually stabilizing.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Publication date: Available online 19 August 2019Source: Pathology - Research and PracticeAuthor(s): Hui Wang, Rani KanthanAbstractAmoebiasis, caused by the intestinal protozoan Entamoeba histolytica, though a relatively common parasitic disease in the tropical and subtropical regions, is uncommon in the developed countries. In these countries, as amoebic colitis shares similar clinical symptoms and endoscopic features with inflammatory bowel disease (IBD), these cases can be easily unrecognized and misdiagnosed.In this case report, we discuss the case of an adult patient with invasive intestinal amoebiasis, who was initia...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
CONCLUSIONS: Therapeutic footwear for diabetics was able to produce significant reductions of peak plantar pressure in static and dynamic analysis, being more efficient than a common footwear, and could contribute to the prevention of injuries associated with diabetic foot.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
Abstract There are>12 million patients with peripheral artery disease in the United States. The most severe form of peripheral artery disease is critical limb ischemia (CLI). The diagnosis and management of CLI is often challenging. Ethnic differences in comorbidities and presentation of CLI exist. Compared with white patients, black and Hispanic patients have higher prevalence rates of diabetes mellitus and chronic renal disease and are more likely to present with gangrene, whereas white patients are more likely to present with ulcers and rest pain. A thorough evaluation of limb perfusion is important in the d...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
More News: Clinical Trials | Cuba Health | Diabetes | Diabetes Mellitus | Diabetic Ulcers | Endocrinology | Genetics | International Medicine & Public Health | Statistics