Neurovascular decoupling in type 2 diabetes mellitus without mild cognitive impairment: Potential biomarker for early cognitive impairment

Publication date: Available online 25 June 2019Source: NeuroImageAuthor(s): Ying Yu, Lin-Feng Yan, Qian Sun, Bo Hu, Jin Zhang, Yang Yang, Yu-Jie Dai, Wu-Xun Cui, Si-Jie Xiu, Yu-Chuan Hu, Chun-Ni Heng, Qing-Quan Liu, Jun-Feng Hou, Yu-Yun Pan, Liang-Hao Zhai, Teng-Hui Han, Guang-Bin Cui, Wen WangAbstractType 2 diabetes mellitus (T2DM) is a significant risk factor for mild cognitive impairment (MCI) and the acceleration of MCI to dementia. The high glucose level induce disturbance of neurovascular (NV) coupling is suggested to be one potential mechanism, however, the neuroimaging evidence is still lacking. To assess the NV decoupling pattern in early diabetic status, 33 T2DM without MCI patients and 33 healthy control subjects were prospectively enrolled. Then, they underwent resting state functional MRI and arterial spin labeling imaging to explore the hub-based networks and to estimate the coupling of voxel-wise cerebral blood flow (CBF)-degree centrality (DC), CBF-mean amplitude of low-frequency fluctuation (mALFF) and CBF- mean regional homogeneity (mReHo). We further evaluated the relationship between NV coupling pattern and cognitive performance (false discovery rate corrected). T2DM without MCI patients displayed significant decrease in the absolute CBF-mALFF, CBF-mReHo coupling of CBFnetwork and in the CBF-DC coupling of DCnetwork. Besides, networks which involved CBF and DC hubs mainly located in the default mode network (DMN). Furthermore, less severe disease and bette...
Source: NeuroImage - Category: Neuroscience Source Type: research