Orchestration of immunoglobulin isotypes, subclasses, and specificities in patients receiving intravenous IgG or subcutaneous immunotherapy and those with chronic rhinosinusitis with nasal polyps: Toward precision medicine

A common principle is illustrated in several different approaches to treating inflammatory disease reported in 3 recent articles published in the Journal: (1) intravenous IgG (IVIG) treatment in patients with autoimmune disease,1 (2) subcutaneous immunotherapy (SCIT) in patients with grass pollen –induced allergic rhinitis,2 and (3) anti-IgE injections in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) targeting IgE.3 In each of these studies, IgE is the immediate cause of the inflammation, irrespective of whether it acts as an antibody or an antigen, and the therapy depend s on the ability of IgG to interfere with the activity of the IgE.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Editorial Source Type: research