Impact of interplay between autophagy and interferon-alpha in HCV and HCV/HIV infection.

In this study, a total number of 40 samples of peripheral blood mononuclear cells (PBMCs) including 20 HCV and 20 HCV/HIV patients before treatment were evaluated. The HCV viral load in both groups was evaluated by semi quantitative real-time PCR. The level of Beclin-1 and IFN-α gene expression was examined in all samples by semi quantitative real-time PCR assay. The median viral load was 8.3×105 copies/ml in HCV group and 2.1×106 copies/ml in HCV/HIV patients. While the expression level of Beclin-1 gene in HCV group was significantly higher, the level of IFN-α expression was lower compared to the HCV/HIV group (P Keywords: autophagy; Beclin gene; HCV; HIV; IFN gene. PMID: 31230454 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31230454?dopt=Abstract

Source: Acta Virologica - June 25, 2019 Category: Infectious Diseases Authors: Lajevardi B, Bamdad T, Choobin H, Jamalidoust M, Namayandeh M Tags: Acta Virol Source Type: research