Cornea nerve fibre state determines analgesic response to tapentadol in fibromyalgia patients without effective endogenous pain modulation

ConclusionsIn chronic pain patients with fibromyalgia, the increase in endogenous pain inhibition by tapentadol was translated into analgesia in patients with a normal CNFS. In those with abnormal CNFS, tapentadol treatment was without analgesic effect.SignificanceIn this double ‐blind randomized placebo‐controlled trial, we showed that tapentadol significantly enhanced the descending pain inhibition in fibromyalgia patients. Tapentadol‐induced pain relief was only present in patients with a normal CNFS.

https://onlinelibrary.wiley.com/doi/abs/10.1002/ejp.1435?af=R

Source: European Journal of Pain - June 23, 2019 Category: Anesthesiology Authors: Tine Donk, Monique Velzen, Albert Dahan, Marieke Niesters Tags: ORIGINAL ARTICLE Source Type: research