Mepolizumab utility in successful aspirin desensitization in aspirin-exacerbated respiratory disease in a refractory case

Aspirin-exacerbated respiratory disease (AERD) is a severe respiratory syndrome characterized by asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), and sensitivity to nonsteroidal anti-inflammatory drugs (NSAID) including aspirin manifested by acute upper and lower respiratory symptoms with exposure to this class of medications. (1) The prevalence of AERD is reported in 5.5% to 12.4 % of adult asthmatics, and rises to 21% when NSAID hypersensitivity is determined by provocation. (2-4) The management of asthma and CRSwNP in AERD should follow international guidelines including use of combination inhaled corticosteroid and long acting beta ‐2 agonists (ICS/LABA), leukotriene‐modifying drugs (LTMD), nasal corticosteroids, nasal saline irrigations and short‐term antibiotics and oral steroids as needed.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research