Molecules, Vol. 24, Pages 2321: Discovery of Novel UV-Filters with Favorable Safety Profiles in the 5-Arylideneimidazolidine-2,4-dione Derivatives Group

Molecules, Vol. 24, Pages 2321: Discovery of Novel UV-Filters with Favorable Safety Profiles in the 5-Arylideneimidazolidine-2,4-dione Derivatives Group Molecules doi: 10.3390/molecules24122321 Authors: Justyna Popiół Agnieszka Gunia-Krzyżak Kamil Piska Dorota Żelaszczyk Paulina Koczurkiewicz Karolina Słoczyńska Katarzyna Wójcik-Pszczoła Anna Krupa Agata Kryczyk-Poprawa Ewa Żesławska Wojciech Nitek Paweł Żmudzki Henryk Marona Elżbieta Pękala Effective protection from the harmful effects of UV radiation may be achieved by using sunscreens containing organic or inorganic UV filters. The number of currently available UV filters is limited and some of the allowed molecules possess limitations such as systemic absorption, endocrine disruption properties, contact and photocontact allergy induction, and low photostability. In the search for new organic UV filters we designed and synthesized a series consisting of 5-benzylidene and 5-(3-phenylprop-2-en-1-ylidene)imidazolidine-2,4-dione (hydantoin) derivatives. The photoprotective activity of the tested compounds was confirmed in methanol solutions and macrogol formulations. The most promising compounds possessed similar UV protection parameter values as selected commercially available UV filters. The compound diethyl 2,2′-((Z)-4-((E)-3-(4-methoxyphenyl)allylidene)-2,5-dioxoimidazolidine-1,3-diyl)diacetate (4g) was characterized as an especially efficient UVA photoprotectiv...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research