Dexmedetomidine: present and future directions.

Dexmedetomidine: present and future directions. Korean J Anesthesiol. 2019 Jun 21;: Authors: Lee S Abstract Dexmedetomidine is a potent, highly selective α-2 adrenoceptor agonist, with sedative, analgesic, anxiolytic, sympatholytic, and opioid-sparing properties. Dexmedetomidine induces a unique sedative response which shows easy transition from sleep to wakefulness, allowing a patient to be cooperative and communicative when stimulated. Dexmedetomidine may produce less delirium compared with other sedatives, or even prevent delirium. Analgesic effect of dexmedetomidine is not strong, however, it can be administered as a useful analgesic adjuvant. Dexmedetomidine decreases the need for opioids, inhalational anesthetics, and intravenous anesthetics as an anesthetic adjuvant. Sympatholytic effect of dexmedetomidine may provide stable hemodynamics in a perioperative period. Dexmedetomidine-induced cooperative sedation with minimal respiratory depression provides a safe and acceptable conditions during neurosurgical procedures in awake patients and awake fiberoptic intubation. Despite the lack of pediatric labelling, dexmedetomidine for pediatric use has been widely studied for various applications. Most adverse events associated with dexmedetomidine occur during or shortly after a loading infusion. There are some case reports of dexmedetomidine-related cardiac arrest following severe bradycardia. Some extended applications of dexmedeto...
Source: Korean Journal of Anesthesiology - Category: Anesthesiology Tags: Korean J Anesthesiol Source Type: research