Intense exercise training is not effective to restore the endothelial NO-dependent relaxation in STZ-diabetic rat aorta

Background: The aim of this study was to examine the effects of intense physical training on vascular function in streptozotocin-diabetic rats. We focused on the endothelium-dependent relaxation (EDR) induced by acetylcholine (ACh) and stable ADP adenosine-5[prime]- O -- (2-thiodiphosphate) (ADPbetaS). Methods: Control or diabetic male Wistar rats (n=44) were randomly assigned to sedentary or trained groups. The training program consisted in a regular period of running on a treadmill during 8 weeks (10[degree sign] incline and up to 25 m/min, 60 min/day). The reactivity of isolated thoracic aorta rings of healthy, diabetic and/or trained has been tested. Results: ACh and ADPbetaS-induced EDR were observed in phenylephrine (PE) pre-contracted vessels. As compared to sedentary control group, diabetic rats showed an increase in PE-induced contraction and a decrease in ACh and ADPbetaS-induced EDR (p
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Source Type: research