Programmed Cell Death in Bacterial Community: Mechanisms of Action, Causes and Consequences.

Programmed Cell Death in Bacterial Community: Mechanisms of Action, Causes and Consequences.
J Microbiol Biotechnol. 2019 Jun 18;:
Authors: Lee H, Lee DG
Abstract
In the bacterial community, unicellular organisms act as a multicellular being. Bacteria interact within the community and the programmed cell death (PCD) in prokaryotes is one of the altruistic actions for the whole population to thrive. Genetically, encoded cell death pathways are triggered by DNA damage or nutrient starvation. Given the environmental and bacterial diversity, different PCD mechanisms are operated. Still, their biochemical and physiological aspects remain unrevealed. There are three main pathways; thymineless death, apoptosis-like death, and toxin-antitoxin system. The discovery of the PCD in bacteria unveil the possibility of targeting new antibiotics. In this review, the molecular and physiological characteristics of the three types of PCD and their development potential as an antibacterial agent are addressed.
PMID: 31216790 [PubMed - as supplied by publisher]

Source: Journal of Microbiology and Biotechnology - June 17, 2019 Category: Biotechnology Authors: Lee H, Lee DG Tags: J Microbiol Biotechnol Source Type: research