Breakthrough pneumonia, meningitis and bloodstream infection due to Streptococcus pneumoniae during cefixime therapy.

We describe three cases of breakthrough pneumococcal severe life-threatening infections, including two meningitis and one bloodstream infection in patients treated with cefixime for otitis, sinusitis and pneumonia, respectively. Cefixime does not seem to be fully effective in treating invasive pneumococcal diseases. Because penicillin non-susceptibility might be linked to cefixime failure, the prompt knowledge of susceptibility to penicillin in S. pneumoniae might be very useful. Furthermore, MIC of cefixime should be measured because values>0.5 mg/L might be related to failure. PMID: 31215358 [PubMed - as supplied by publisher]
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research

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(Karolinska Institutet) Pneumococci are the most common cause of respiratory tract infections, such as otitis and sinusitis, as well as of severe infections like pneumonia and meningitis. A new study from Karolinska Institutet in Sweden published in Nature Microbiology shows how the bacteria can inhibit immune cell reaction and survive inside cells to give rise to pneumonia.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Streptococcus pneumoniae (pneumococcus) is a major cause of acute otitis media, sinusitis, pneumonia and meningitis worldwide [1]. More than 1.2 million infant deaths are attributed to S. pneumoniae annually [2].
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
CONCLUSION: The results from this study suggest that our NTHi AOM coinfection model is useful for assessing protein vaccines. PMID: 30136923 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research
Calvin Green, Christine Ann Moore, Akhilesh Mahajan, Kailash BajajJournal of Global Infectious Diseases 2018 10(3):159-162 Streptococcus pneumoniae is a bacterium responsible for a spectrum of diseases including lobar pneumonia, meningitis, otitis media, and sinusitis. Invasive pneumococcal disease is responsible for significant morbidity and mortality across the world. Concerted efforts led to the development of two vaccinations, Pneumova × 23 and Prevnar 13, for the prevention of pneumococcal disease. The Advisory Committee on Immunization Practices of the US Centers for Disease Control and Prevention provides vacc...
Source: Journal of Global Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Care of infectious diseases (prevention, diagnosis, and treatment) represents a large part of the activity of pediatric practices as well as primary care, emergency departments, and hospitals. The bacterial and viral species involved in pediatric community-acquired infections (CAIs) can induce severe, moderate, or mild diseases, which require care by hospitalization, emergency departments, or first-line clinicians. For example, pneumococcus manifests as a spectrum of diseases ranging from severe invasive diseases, such as meningitis, bacteremic pneumonia, and bacteremia, to less severe but more frequent diseases, such as a...
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: European Pediatric Association Source Type: research
Publication date: February 2018 Source:Microbial Pathogenesis, Volume 115 Author(s): Abdul Wadood, Alam Jamal, Muhammad Riaz, Ajmal Khan, Reaz Uddin, Musharraf Jelani, Syed Sikander Azam Streptococcus pneumoniae (pneumococcus) is a Gram-positive bacterium. Humans are the major target for the pneumococcus. The pneumococcus is a common etiological agent of many different diseases such as bacterial meningitis, pneumonia, otitis media (OM), sinusitis, and conjunctivitis. According to the WHO, the pneumococcus is responsible for causing 1 million deaths each year. In 2000, over 14 million children worldwide under the age of 5 ...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
In previous studies of pneumococcal meningitis in adults within general hospitals or national cohorts, the most common predisposing conditions were otitis media, sinusitis, pneumonia, immunosuppression, alcoholism, and diabetes. The epidemiology of pneumococcal meningitis is changing because of the use of vaccines in childhood, and antibiotic resistance has increased.
Source: World Neurosurgery - Category: Neurosurgery Authors: Tags: Original Article Source Type: research
In previous studies of pneumococcal meningitis in adults within general hospitals or national cohorts, the most common predisposing conditions are otitis media, sinusitis, pneumonia, immunosuppression, alcoholism, and diabetes. The epidemiology of pneumococcal meningitis is changing due to the use of vaccines in childhood, and antibiotic resistance has increased.
Source: World Neurosurgery - Category: Neurosurgery Authors: Tags: Original article Source Type: research
AbstractStreptococcus pneumoniae causes meningitis, pneumonia, septicemia, arthritis, sinusitis and otitis media specially in children and over 65 y age groups. It contributes significantly to under-five mortality and morbidity worldwide as well as in India. Use of pneumococcal vaccine seems to be the most effective measure to decrease the disease burden and reduction of under-five mortality. Many countries have already included Pneumococcal Conjugate Vaccines (PCV) in their National Immunization Programmes (NIP). Government of India has announced recently to include PCV13 in NIP in a phased manner. Superiority of a vaccin...
Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
Authors: K L Ç H, Akyol S, Parkan ÕM, Dinç G, Sav H, Aydemir G Abstract Haemophilus influenzae can cause invasive and severe infections in both adults and children such as otitis media, sinusitis, pneumonia, meningitis and bacteremia. The emerging antibiotic resistance in recent years against ampicillin and several other antibiotics among strains of H. influenzae gives cause for serious concern. Here, we investigate ß-lactamase (BL) activity in clinical isolates of H. influenzae, profile their resistance to antibiotics, and characterize the clonal relationship of the isolates. Antibiotic ...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
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