Diabetic hemodialysis: vitamin D supplementation and its related signaling pathways involved in insulin and lipid metabolism.

CONCLUSIONS: Our findings confirmed, diabetic HD subjects who were received the vitamin D supplementation (for 12 weeks), show a significant over expression in the PPAR-γ, AKT, PI3K, IRS1 and GLUT4 genes, and also show a significant down regulation in the PKC and LDLR genes. Moreover, did not observe any effects on PDK1, IRS2 and Lp(a) expression.
PMID: 31210105 [PubMed - as supplied by publisher]

Source: Current Molecular Medicine - June 17, 2019 Category: Molecular Biology Authors: Hosseini ES, Kashani HH, Nikzad H, Soleimani A, Mirzaei H, Tamadon MR, Asemi Z Tags: Curr Mol Med Source Type: research