Spontaneous colitis in IL-10-deficient mice was ameliorated via inhibiting glutaminase1.

In conclusion, inhibition of Gls1 expression attenuated chronic colitis by maintaining intestinal barrier integrity and the Th/Treg balance, thereby ameliorating CD-like colitis.
PMID: 31211512 [PubMed - as supplied by publisher]

Source: J Cell Mol Med - June 17, 2019 Category: Molecular Biology Authors: Li J, Zuo L, Tian Y, He Y, Zhang Z, Guo P, Ge Y, Hu J Tags: J Cell Mol Med Source Type: research