Systemic activation of the complement system in patients with advanced age-related macular degeneration.

CONCLUSION: We suggest a role for elevated plasma levels of C3a and sC5b-9 in patients with neovascular age-related macular degeneration. The study's results reinforce the need for more investigation to assess the impact of therapeutic interventions targeted at the complement signaling pathways in age-related macular degeneration.
PMID: 31203676 [PubMed - as supplied by publisher]

Source: European Journal of Ophthalmology - June 16, 2019 Category: Opthalmology Authors: Lynch AM, Mandava N, Patnaik JL, Frazer-Abel AA, Wagner BD, Palestine AG, Mathias MT, Siringo FS, Cathcart JN, Holers VM Tags: Eur J Ophthalmol Source Type: research