Two New Isoflavones from the Flowers of Rosa damascena and Their Biological Activities

Two new isoflavones, 6-hydroxy-7-(3-hydroxypropyl)-4 ′-methoxyisoflavone (1) and 6,4 ′-dihydroxy-7-(3-hydroxypropyl)-isoflavone (2), were isolated from the flowers ofRosa damascena. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds1 and2 were evaluated for their anti-methicillin-resistantStaphylococcus aureus (anti-MRSA) activity. The results revealed that compounds1 and2 showed weak inhibition with IZD of 11.6 ± 1.2 and 11.2 ± 1.0 mm, respectively. Compounds1 and2 were also tested for their antioxidant activity and showed good activity with an IC50 value of 4.2 and 4.0 μg/mL, respectively.
Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research