Pathological Pattern of Intrahepatic HBV in HCC is Phenocopied by PDX-Derived Mice: a Novel Model for Antiviral Treatment.

CONCLUSION: We delineated pathological HBV profiles of HCC specimens and perilesional areas, which provided evidence for virus-based therapy in the future. PDX mice may phenocopy virological and cellular features of patient tissues, which is novel in the virus-related hepatocarcinogenesis field.
PMID: 31202090 [PubMed - as supplied by publisher]

Source: Translational Oncology - June 11, 2019 Category: Cancer & Oncology Authors: Liu J, Chen S, Zou Z, Tan D, Liu X, Wang X Tags: Transl Oncol Source Type: research