Constitutional abnormality of nuclear membrane proteins in small cell lung carcinoma

In conclusion, we suggest tha t downregulation of the nuclear membrane proteins emerin and lamin A/C is characteristic of SCLC cells, and this constitutional abnormality of the nuclear membrane may be related to the biological and/or clinical nature of SCLC. In addition, knowing the nuclear protein profile in SCLC cells may cont ribute to our understanding of nuclear fragility known as the crush artifact in pulmonary biopsy specimens.
Source: Virchows Archiv - Category: Pathology Source Type: research