Transcriptional repression of the tyrosinase-related protein 2 gene by transforming growth factor- β and the Kruppel-like transcription factor GLI2
Tyrosinase-Related Protein 2 (TRP2) is an enzyme involved in melanogenesis, that also exerts proliferative, anti-apoptotic and immunogenic functions in melanoma cells. TRP2 transcription is regulated by the melanocytic master transcription factor MITF. GLI2, a transcription factor that acts downstream of Hedgehog signaling, is also a direct transcriptional target of the TGF- β/SMAD pathway that contributes to melanoma progression and exerts transcriptional antagonistic activities against MITF.
Source: Journal of Dermatological Science - Category: Dermatology Authors: Marie-Jeanne Pierrat, V éronique Marsaud, Alain Mauviel, Delphine Javelaud Source Type: research