Testicular rhabdomyosarcoma after chemotherapy for metastatic germ cell tumors

AbstractA 36-year-old male was referred to our hospital with left scrotal swelling. Computed tomography revealed a massive tumor in his left scrotum. The tumor extended along the gonadal vein extraperitoneally forming a massive tumor. Pathological examination showed a mixed-type germ cell tumor. Despite several chemotherapeutic treatments, the tumor continued to grow, and the patient died 28  months later after his first presentation at our institution. Autopsy revealed that the tumor comprised rhabdomyosarcoma and mature teratoma. We could not find useful tumor markers to facilitate the diagnosis of rhabdomyosarcoma. However, we recommend rebiopsy or palliative operation as options fo r re-diagnosis in case of resistant germ cell tumor. Here, we present a case of testicular tumor that exhibited different pathological examination results before and after treatment.
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research

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This study compares the rate of bone integrity and bone resorption of the coracoid process, and the clinical outcomes after the Bristow procedure in 61 shoulders and the Latarjet procedure in 44 shoulders with at least one year of follow-up. CT scans showed 98% of bone union of the coracoid process within 3 months after the Latarjet procedure, but only 78% of bone union, 15% of delayed union, and 7 % of fracture of the coracoid in the Bristow procedure, 6 months after surgery.
Source: Journal of Shoulder and Elbow Surgery - Category: Orthopaedics Authors: Source Type: research
ABSTRACT Objective Review the diet and nutritional status of women surviving breast cancer following the Dietary Guidelines for the Brazilian Population. Methods A cross-sectional study was conducted with 201 women, who underwent anthropometric measurements to determine body mass index, waist circumference and waist/hip ratio. Dietary assessment was performed usinga food frequency questionnaire. Consumption was stratifi ed into four groups: fresh/minimally processed food (Group 1), processed food ingredients (Group 2), processed food (Group 3) and ultra-processed food (Group 4).The ratio of daily contribution of each food ...
Source: Revista de Nutricao - Category: Nutrition Source Type: research
This study was conducted to enhance the rate of advance care planning conversations and documentation by improving knowledge, attitudes, and skills of caregivers.      Read more   Violence and Trauma ...
Source: Johns Hopkins University and Health Systems Archive - Category: Nursing Source Type: news
Publication date: Available online 16 October 2019Source: Pharmacology &TherapeuticsAuthor(s): Stephen J. Bagley, Donald M. O’RourkeAbstractChimeric antigen receptor (CAR) T cells are a form of autologous immunotherapy that has changed the therapeutic landscape of hematologic malignancies. CAR T cell therapy involves collection of a patient’s T cells by apheresis, ex vivo genetic modification of the T cells to encode a synthetic receptor that binds a specific tumor antigen, and infusion of the T cells back into the patient. With the unprecedented success of CAR T cells in leukemia and lymphoma, a growing nu...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 16 October 2019Source: Pharmacology &TherapeuticsAuthor(s): Suya Wang, Jianshi Yu, Maureen A. Kane, Alexander R. MoiseAbstractThe vitamin A metabolite, retinoic acid, is an important signaling molecule during embryonic development serving critical roles in morphogenesis, organ patterning and skeletal and neural development. Retinoic acid is also important in postnatal life in the maintenance of tissue homeostasis, while retinoid-based therapies have long been used in the treatment of a variety of cancers and skin disorders. As the number of people living with chronic disorders continu...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 16 October 2019Source: Pharmacological ResearchAuthor(s): Siqi Feng, Huan Wang, Jiali Liu, Jiye AA, Fang Zhou, Guangji WangAbstractKetone bodies are traditionally viewed as metabolic substrates in carbohydrate restriction and are applied in the treatment of epilepsy and other neurodegenerative diseases. Recently, people have paid more attention to its application in the treatment for cancers. Compared to normal cells, cancer cells maintain a higher level of reactive oxygen species (ROS) due to the dysfunctional oxidative phosphorylation and they highly rely on glucose for glycolysis and p...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Conclusions: Our findings suggested that Dulcitol acted as a SIRT1 inhibitor, inducing apoptosis and inhibiting proliferation, migration and invasion of HepG2 cells and its modulatory mechanism seemed to be associated with regulation of MMPs, SIRT1/p53 pathways.Graphical abstractSchematic diagram of the proposed mechanisms of Dulcitol-induced apoptosis and anti-metastasis in hepatocellular carcinoma in vivo and in vitro.
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Abstract The species Kalanchoe laciniata (L.) DC. and Bryophyllum pinnatum (Lam) Pers. are native from Brazil and Madagascar, respectively. Both belonging to the Crassulaceae family and being widely used by population as a natural anti-inflammatory agent. These species have similar leaf morphology and for this reason, they are known by the same popular name as “ sai ão ” or “ coirama ” . Several studies have been published involving different parts and preparations of these species. Therefore, this review aims to provide an update overview about the traditional uses, chemical constitution, ph...
Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research
Garner posted a video on Instagram, and it ’s already “Garnered” over 1.7 million views and over 300,000 likes.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Mohammed AbomelhaUrology Annals 2017 9(4):305-309There is a paucity of data regarding testicular cancer among Saudis as well as the nonexistent of published national data. Furthermore, a substantial increase of the incidence of testicular cancer among Saudis was lately noted. The aim of the study is to determine the trends and patterns of testicular cancer among adult Saudis using national data over a period of 20 years. The national database of the Saudi Cancer Registry (SCR) on testicular cancer over the last two decades was studied including epidemiological and histological patterns. The 1004 cases of testicular cancer ...
Source: Urology Annals - Category: Urology & Nephrology Authors: Source Type: research
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