Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis

Conclusion: These results suggest that, contrary to common assumption, maintaining PD-L1 expression on hepatocytes improves liver damage and survival of mice during sepsis. We conclude that administering recombinant PD-L1 or inhibiting NOX2 activity might offer a new therapeutic option in sepsis.

Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Andreas von Knethen, Anne Sch ä fer, Laura Kuchler, Tilo Knape, Urs Christen, Edith Hintermann, Beate Fi ß lthaler, Katrin Schr ö der, Ralf P. Brandes, Berit Genz, Kerstin Abshagen, Brigitte M. P ü tzer, Lisa K. Sha, Andreas Weigert, Shahzad N. Syed, Tags: Research Paper Source Type: research