Anxiolytic Impact of Apelin-13 in a Rat Model of Alzheimer's Disease: Involvement of Glucocorticoid Receptor and FKBP5

Publication date: Available online 11 June 2019Source: PeptidesAuthor(s): Samaneh Aminyavari, Maryam Zahmatkesh, Fariba Khodagholi, Mehdi SanatiAbstractApelin-13 is known to be one of the predominant neuropeptides with marked protective role in circuits involved in mood disturbances. The most putative hypothesis in pathophysiology of Alzheimer's disease (AD) is Amyloid beta (Aβ) aggregation which interrupt proper function of hypothalamic–pituitary–adrenal (HPA) axis and are associated with anxiety. Here, we assessed the potential anxiolytic effect of Apelin-13 in a rodent cognitive impairment model induced by intrahippocampal Aβ25-35 administration. We evaluated the memory impairment and anxiogenic behavior using shuttle box and Elevated plus maze apparatuses. We also measured the glucocorticoid receptor (GR) and FK506 binding protein 51 (FKBP5) expression as important markers showing the proper feedback mechanism within the HPA axis.Our findings showed that Aβ25-35 administration induced memory impairment and anxiety behaviors. Apelin-13 exerted the anxiolytic effects and provided protection against Aβ25-35-induced passive avoidance memory impairment. Moreover, Apelin-13 caused an increase in GR and a decrease in FKBP5 expression levels in Aβ25-35 treated animals.Taken together, these findings showed the anxiolytic effect of Apelin-13. This effect at least in part, may be mediated through the regulation of GR and FKBP5 expression levels w...
Source: Peptides - Category: Biochemistry Source Type: research

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A component in cannabis called CBD is claimed to help everything from Alzheimer's to anxiety. Despite a boom in sales, there's little evidence supporting the claims
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
A component in cannabis called CBD is claimed to help everything from Alzheimer's to anxiety. Despite a boom in sales, there's little evidence supporting the claims
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
Conclusion: Interventions directed at the promotion of the QoL of patients with mild AD should focus on the promotion of mindfulness skills in AD patients, in addition to the reduction of psychological morbidity and the promotion of functionality, awareness of the disease, family relationships and social support. PMID: 31411042 [PubMed - as supplied by publisher]
Source: Aging and Mental Health - Category: Geriatrics Authors: Tags: Aging Ment Health Source Type: research
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Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Regular Research Article Source Type: research
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Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine alzheimer Alzheimer's disease brain cognitive health dementia digital digital health elderly elderly care Healthcare Innovation medical technology Source Type: blogs
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Source: Current Opinion in Psychiatry - Category: Psychiatry Tags: GERIATRIC PSYCHIATRY: Edited by Orestes Forlenza and Claudia Cooper Source Type: research
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Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
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