TIMELESS mutation alters phase responsiveness and causes advanced sleep phase [Neuroscience]

Many components of the circadian molecular clock are conserved from flies to mammals; however, the role of mammalian Timeless remains ambiguous. Here, we report a mutation in the human TIMELESS (hTIM) gene that causes familial advanced sleep phase (FASP). Tim CRISPR mutant mice exhibit FASP with altered photic entrainment but...

http://www.pnas.org/content/116/24/12045.short?rss=1

Source: Proceedings of the National Academy of Sciences - June 10, 2019 Category: Science Authors: Philip Kurien, Pei–Ken Hsu, Jacy Leon, David Wu, Thomas McMahon, Guangsen Shi, Ying Xu, Anna Lipzen, Len A. Pennacchio, Christopher R. Jones, Ying–Hui Fu, Louis J. Ptaček Tags: PNAS Plus Source Type: research