Germline BRCA1 Mutation Detected in a Multiple Endocrine Neoplasia Type 2 Case With RET Codon 634 Mutation

Conclusion: Coincidence of two monogenic autosomal dominant tumor syndromes is extremely rare, representing significant therapeutic and cancer surveillance challenges. Due to the wider use of next generation sequencing in clinical practice similar situations may occur more frequently.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research