Nucleolus: A Central Hub for Nuclear Functions.

Nucleolus: A Central Hub for Nuclear Functions. Trends Cell Biol. 2019 Jun 05;: Authors: Iarovaia OV, Minina EP, Sheval EV, Onichtchouk D, Dokudovskaya S, Razin SV, Vassetzky YS Abstract The nucleolus is the largest and most studied nuclear body, but its role in nuclear function is far from being comprehensively understood. Much work on the nucleolus has focused on its role in regulating RNA polymerase I (RNA Pol I) transcription and ribosome biogenesis; however, emerging evidence points to the nucleolus as an organizing hub for many nuclear functions, accomplished via the shuttling of proteins and nucleic acids between the nucleolus and nucleoplasm. Here, we discuss the cellular mechanisms affected by shuttling of nucleolar components, including the 3D organization of the genome, stress response, DNA repair and recombination, transcription regulation, telomere maintenance, and other essential cellular functions. PMID: 31176528 [PubMed - as supplied by publisher]
Source: Trends in Cell Biology - Category: Cytology Authors: Tags: Trends Cell Biol Source Type: research