Effect of the key histone modifications on the expression of genes related to breast cancer.

Effect of the key histone modifications on the expression of genes related to breast cancer.
Genomics. 2019 Jun 03;:
Authors: Jin W, Li QZ, Liu Y, Zuo YC
Abstract
Abnormal histone modifications (HMs) and transcription factors (TFs) can alter the expression of cancer-related genes to promote tumorigenesis. We studied the variations of 11 HMs and 2 TFs in human breast cancer cells (MCF-7) compared to human normal mammary epithelial cells (HMEC), and the effects of HMs/TFs in various regions of the genome on the expression changes of breast cancer-related genes. Based on HMs and TFs signals' differences between MCF-7 and HMEC flanking TSSs, the up- and down-regulated genes in MCF-7 were predicted by Random Forest, and important HMs and regions were found. Results indicate that H3K79me2, H3K27ac, and H3K4me1 are particularly important for the changes of gene expression in MCF-7. Especially, H3K79me2 around the 60-th bin flanking TSSs may be the key for regulating gene expression. Our studies reveal H3K79me2 may be a core HM for breast cancer.
PMID: 31170440 [PubMed - as supplied by publisher]

Source: Genomics - June 2, 2019 Category: Genetics & Stem Cells Authors: Jin W, Li QZ, Liu Y, Zuo YC Tags: Genomics Source Type: research