The Small Bowel Cancer Incidence Enigma.

The Small Bowel Cancer Incidence Enigma. Pathol Oncol Res. 2019 Jun 05;: Authors: Assumpção P, Khayat A, Araújo T, Barra W, Ishak G, Cruz A, Santos S, Santos Â, Demachki S, Assumpção P, Calcagno D, Santos N, Assumpção M, Moreira F, Santos A, Assumpção C, Riggins G, Burbano R Abstract Although the small bowel is a vast organ with a highly proliferative epithelium, the incidence of small bowel cancers is surprisingly low. Many factors could be involved in this unexpected cancer incidence, including difficult access to the exploration of the small bowel mucosa, which might lead to missed diagnoses of non-obstructive and non-bleeding small tumours. Moreover, possible factors that influence the low incidence include more efficient machinery of DNA replication and DNA repair enzymes, peculiarities in microbiota components, competence of the immune system, and the speed of intestinal transit. Importantly, the answer for the enigmatic risk of driver mutations caused by replication errors may be hidden in the small bowel, which is an obscure part of digestive tract that is usually inaccessible by endoscopic or colonoscopic conventional investigations. These observations warrant the necessity of an urgent exploration of small bowel features, including the evaluation of DNA replication controls and expression of DNA repair genes, in order to shed light on these obscure events. PMID: 31165996 ...
Source: Pathology Oncology Research - Category: Pathology Authors: Tags: Pathol Oncol Res Source Type: research

Related Links:

This study was carried out in accordance with approval of the Melbourne Health and Walter and Eliza Hall Institute of Medical Research's Human Research Ethics Committee (approval number: 2013.081). All subjects gave written informed consent for participation and publication. Results and Discussion TGF-β signaling in NK cells is associated with: phosphorylation in SMAD2 and 3, inhibition of IL-15-induced metabolism/proliferation, simultaneous downregulation of CD44, CD49e, and Eomes, and upregulation of CD16 and CD49a expression (7, 10). SMAD family member 4 (SMAD4) belongs to the SMAD family of transcription...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSIONS: There is a higher than expected risk that if a cancer is diagnosed in a patient presenting with either an isolated change in bowel habit or a combination of change in bowel habit with rectal bleeding, the cancer may be right sided. PMID: 30855983 [PubMed - as supplied by publisher]
Source: Annals of the Royal College of Surgeons of England - Category: Surgery Authors: Tags: Ann R Coll Surg Engl Source Type: research
Publication date: Available online 19 November 2018Source: The LancetAuthor(s): Mark A Hull, Kirsty Sprange, Trish Hepburn, Wei Tan, Aisha Shafayat, Colin J Rees, Gayle Clifford, Richard F Logan, Paul M Loadman, Elizabeth A Williams, Diane Whitham, Alan A Montgomery, seAFOod Collaborative GroupSummaryBackgroundThe omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) and aspirin both have proof of concept for colorectal cancer chemoprevention, aligned with an excellent safety profile. Therefore, we aimed to test the efficacy of EPA and aspirin, alone and in combination and compared with a placebo, in individuals w...
Source: The Lancet - Category: General Medicine Source Type: research
BOWEL cancer symptoms include unexplained weight loss, bleeding or finding blood in your poo, or feeling very tired for no reason. But how much weight should you lose before seeing a doctor? Losing this much weight in a short space of time could be a bowel cancer sign.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
BOWEL cancer symptoms include unexplained weight loss, bleeding or finding blood in your poo, or feeling very tired for no reason. But how much weight should you lose before seeing a doctor? Losing this much weight in a short space of time could be a bowel cancer sign.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: Few patients initially suspected bowel cancer or reported embarrassment seeking care; those who did were most likely to experience changes in bowel habit or bleeding. Our study is small, and not representative of all those diagnosed with CRC in New Zealand; yet it provides important first insights into patients' diagnostic experiences. PMID: 30286063 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
BOWEL cancer symptoms include bleeding from your behind, unexplained weight loss and stomach pains. According to Cancer Research UK, more than half of all bowel cancer cases could have been prevented. You can reduce your risk by changing your diet and lifestyle.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
BOWEL cancer symptoms consist of bleeding from the bottom, fatigue and weight loss amongst others. However, as many as 95 per cent of participants in a recent poll said they would not be able to identify the condition, the UK ’s second biggest killer.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
BOWEL cancer symptoms include bleeding from your behind, unexplained weight loss and extreme tiredness. Its cause is unknown, but diet, smoking, and alcohol consumption may all be factors. The condition may be easily avoided by taking simple preventative measures such as eating more fibre.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
BOWEL cancer symptoms are not always obvious but, as one of the most common types of cancer diagnosed in the UK, it is important to recognise the signs. Bleeding from your bottom or blood in your poo can indicate the disease, but the colour of the blood could be a sign of a completely different health condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
More News: Bleeding | Bowel Cancer | Cancer | Cancer & Oncology | Gastroschisis Repair | Genetics | Pathology