Comment on Myocardial Perfusion Study in Obese Patients without Known Cardiac Ischemia

Abstract Chronic hyperglycemia is the key point of macro- and microvascular complications associated with diabetes mellitus. Excess glucose is responsible for inducing redox imbalance and both systemic and intrarenal inflammation, playing a critical role in the pathogenesis of diabetic kidney disease, which is currently the leading cause of dialysis in the world. The pathogenesis of the disease is complex, multifactorial and not fully elucidated; many factors and mechanisms are involved in the development, progression and clinical outcomes of the disease. Despite the disparate mechanisms involved in renal damage related to diabetes mellitus, the metabolic mechanisms involving oxidative/inflammatory pathways are widely accepted. The is clear evidence that a chronic hyperglycemic state triggers oxidative stress and inflammation mediated by altered metabolic pathways in a self-perpetuating cycle, promoting progression of cell injury and of end-stage renal disease. The present study presents an update on metabolic pathways that involve redox imbalance and inflammation induced by chronic exposure to hyperglycemia in the pathogenesis of diabetic kidney disease.Resumo A hiperglicemia cr ônica é o ponto-chave das complicações macro e microvasculares associadas ao diabetes mellitus. O excesso de glicose é responsável por induzir desequilíbrio redox e inflamação sistêmica e intra-renal, desempenhando um papel crí...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research

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AbstractBackgroundType 2 diabetes mellitus (T2DM) with central obesity is a common clinical presentation in Chinese patients. Body mass index (BMI) is a criterion determining central obesity that, when combined with dual-energy X-ray absorptiometry (DXA), accurately reflects body composition and fat mass distribution. The utility of DXA-derived measures in the evaluation of metabolic surgery still needs to be investigated.MethodsIn this cohort study, 78 Chinese patients with central obesity (WC  ≥ 90 cm for males, WC ≥ 85 cm for females) or BMI above 27.5 kg/m2 underwent gas...
Source: Obesity Surgery - Category: Surgery Source Type: research
The objective of this study was to determine the association of Computed tomography quantified visceral (VAT) and subcutaneous adipose tissue (SAT) with estimated glomerular filtration rate (eGFR) using CKD-EPI formula, diabetes mellitus, body mass index (BMI), proteinuria, lipid profile, and hypertension. Increased adipose tissue is the primary phenotypic characteristic of obesity. The amount and distribution of adipose tissue is associated with many adverse consequences, as hypertension, type 2 diabetes, cardiovascular disease etc. Abdominal CT with semi-automated software can quantify adipose tissue and predict the risk...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusion: This pilot study showed that a diabetes specific nutritional supplement was useful in improving glycemic control and reducing glycemic response in overweight and obese Asian Indian adults with T2DM. PMID: 31801326 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
ska M Abstract In the study, 305 patients of both genders were enrolled and divided into three groups: obese (BMI> 30 kg/m2), patients who were diagnosed type 2 diabetes mellitus (T2DM), and control, normal weight healthy volunteers. At least one of ten different phthalate metabolites was determined in the urine samples of 49.84% all enrolled participants. In the obese subgroup, the sum of all urinary phthalate metabolites was positively associated with TG levels (p = 0.031) together with derived TC/HDL and TG/HDL ratios (p = 0.023 and 0.015), respectively. Urinary MEP concentration was positively correlated wi...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
ConclusionsChildren with obesity and increased liver transaminases as surrogates of NAFLD should be screened for T2DM.
Source: Pediatric Obesity - Category: Eating Disorders & Weight Management Authors: Tags: ORIGINAL RESEARCH Source Type: research
DiscussionThis overview will assess current evidence from systematic reviews for the association between cadmium exposure and risk of T2DM and other metabolic morbidities. This overview may be helpful for policy-makers and healthcare teams aiming to mitigate T2DM risk in populations at risk of cadmium exposure.Systematic review registrationPROSPERO CRD42019125956
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
AbstractPurposesBiliopancreatic diversion could improve type 2 diabetes mellitus. Our aim was to investigate the effects of biliary jejunostomy on the improvement of glucose.Materials and MethodsTwenty-seven type 2 diabetes patients underwent biliary jejunostomy between January 2013 and January 2018 in our hospital and were followed up. Demographic data, operation details, body weight, food intake, effects on diabetes control, and biomedical parameters were collected and analyzed.ResultsAs defined previously, 3 of 27 diabetes patients were “under control,” 8 patients were “in remission,” and 12 pati...
Source: Obesity Surgery - Category: Surgery Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Authors: Lin CH, Shao L, Zhang YM, Tu YJ, Zhang Y, Tomlinson B, Chan P, Liu Z Abstract Introduction: The prevalence of obesity is increasing worldwide and associated conditions, particularly type 2 diabetes mellitus (T2DM), also show increasing prevalence. Lifestyle intervention should be the first line of management for obesity but additional pharmacotherapy is often required and bariatric surgery is appropriate in more severe cases. Drugs acting as glucagon-like peptide-1 receptor agonists (GLP-1RAs) developed for the management of T2DM reduce body weight and liraglutide is the first GLP-1RA to be approved for th...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Preclinical studies have suggested the antitumorigenic properties of metformin on prostate cancer; results from epidemiological studies remain contradictory. We aim to investigate the evidence of metformin and the risk of prostate cancer. PubMed, Embase, Cochrane Library, and Web of Science databases were searched for eligible studies. Meta-analyses were carried out using the most fully adjusted hazard ratios and the corresponding 95% confidence intervals. Eighteen cohort studies and six case–control studies representing 2 009 504 male patients with type 2 diabetes mellitus were identified. The pooled HR of prostate ...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Prostate Cancer Source Type: research
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