Insulin-like Growth Factor 1 Modulates the Phosphorylation, Expression, and Activity of Organic Anion Transporter 3 through Protein Kinase A Signaling Pathway

In conclusion, our study demonstrated that IGF-1 regulates OAT3 expression and transport activity through PKA signaling pathway, possibly by phosphorylating the transporter.Graphical abstractIGF-1/PKA signaling pathway regulates OAT3 phosphorylation, expression and transport activity.
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research