Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models

Targeting the epidermal growth factor receptor (EGFR) either alone or in combination with chemotherapy is an effective treatment for patients with RAS wild-type metastatic colorectal cancer (mCRC). However, only ...

Source: Journal of Experimental and Clinical Cancer Research - June 4, 2019 Category: Cancer & Oncology Authors: Valentina Belli, Nunzia Matrone, Stefania Napolitano, Giorgia Migliardi, Francesca Cottino, Andrea Bertotti, Livio Trusolino, Erika Martinelli, Floriana Morgillo, Davide Ciardiello, Vincenzo De Falco, Emilio Francesco Giunta, Umberto Bracale, Fortunato Ci Tags: Research Source Type: research