From old to new — Repurposing drugs to target mitochondrial energy metabolism in cancer

Publication date: Available online 4 June 2019Source: Seminars in Cell & Developmental BiologyAuthor(s): Sepideh Aminzadeh-Gohari, Daniela D. Weber, Silvia Vidali, Luca Catalano, Barbara Kofler, René G. FeichtingerAbstractAlthough we have entered the era of personalized medicine and tailored therapies, drugs that target a large variety of cancers regardless of individual patient differences would be a major advance nonetheless. This review article summarizes current concepts and therapeutic opportunities in the area of targeting aerobic mitochondrial energy metabolism in cancer. Old drugs previously used for diseases other than cancer, such as antibiotics and antidiabetics, have the potential to inhibit the growth of various tumor entities. Many drugs are reported to influence mitochondrial metabolism. However, here we consider only those drugs which predominantly inhibit oxidative phosphorylation.
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research