The Practical Significance of Measurement Error in Pulmonary Function Testing Conducted in Research Settings

AbstractConventional spirometry produces measurement error by using repeatability criteria (RC) to discard acceptable data and terminating tests early when RC are met. These practices also implicitly assume that there is no variation across maneuvers within each test. This has implications for air pollution regulations that rely on pulmonary function tests to determine adverse effects or set standards. We perform a Monte Carlo simulation of 20,902 tests of forced expiratory volume in 1 second (FEV1), each with eight maneuvers, for an individual with empirically obtained, plausibly normal pulmonary function. Default coefficients of variation for inter ‐ and intratest variability (3% and 6%, respectively) are employed. Measurement error is defined as the difference between results from the conventional protocol and an unconstrained, eight‐maneuver alternative. In the default model, average measurement error is shown to be ∼5%. The minimum di fference necessary for statistical significance atp
Source: Risk Analysis - Category: International Medicine & Public Health Authors: Tags: Original Research Article Source Type: research

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We examined 86 ACOS patients without cardiovascular disease and thyroid dysfunction. Spirometry, echocardiography, 24-h electrocardiography monitoring, daily pulse oximetry (min% SpO2), blood pressure monitoring and determination of C-reactive protein (CRP) by latex immunoassay were performed. Health status was assessed using the CAT questionnaire.We found AF paroxysms in 42 ACOS patients. ACOS and AF group had more intensive systemic inflammation(CRP levels was 2.5 times higher than in group without rhythm disturbance), lower forced expiratory volume in 1 sec (FEV1) (by 36.5%, p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory function technologists/scient. Source Type: research
Conclusion: As expected, spirometry consistently allows to quantify a loss of pulmonary capacity in respiratory diseases. Sputum rheology offers a complementary marker of the patient condition with strong variations observed, at least for CF and COPD, which suggests its potential to monitor more finely the patient’s evolution.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
AbstractConventional spirometry produces measurement error by using repeatability criteria (RC) to discard acceptable data and terminating tests early when RC are met. These practices also implicitly assume that there is no variation across maneuvers within each test. This has implications for air pollution regulations that rely on pulmonary function tests to determine adverse effects or set standards. We perform a Monte Carlo simulation of 20,902 tests of forced expiratory volume in 1 second (FEV1), each with eight maneuvers, for an individual with empirically obtained, plausibly normal pulmonary function. Default coeffic...
Source: Risk Analysis - Category: International Medicine & Public Health Authors: Tags: Original Research Article Source Type: research
Yafei Tan1,2, Omer Van den Bergh2, Jiang Qiu1* and Andreas von Leupoldt2* 1Faculty of Psychology, Southwest University, Chongqing, China 2Health Psychology, KU Leuven, Leuven, Belgium Dyspnea is a prevalent interoceptive sensation and the aversive cardinal symptom in many cardiorespiratory diseases as well as in mental disorders. Especially the unpredictability of the occurrence of dyspnea episodes has been suggested to be highly anxiety provoking for affected patients. Moreover, previous studies demonstrated that unpredictable exteroceptive stimuli increased self-reports and electrophysiological responses of an...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Objective : Spirometry is a commonly used method of measuring lung function. It is useful in the definitive diagnosis of diseases such as asthma and chronic obstructive pulmonary disease (COPD). However, spirometry requires cooperative patients, experienced staff, and repeated testing to ensure the consistency of measurements. There is discomfort associated with spirometry and some patients are not able to complete the test. In this paper, we investigate the possibility of using cough sound analysis for the prediction of spirometry measurements. Approach : Our approach is based on the premise that the mechanism of co...
Source: Physiological Measurement - Category: Physiology Authors: Source Type: research
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