Synthesis and biological tests of I-123-labeled L- and D-iodohistidine for non-small cell lung cancer imaging

Conclusions: 123I-labeled L- and D-iodohistidine were synthesized by a simple iodogen method with a high radiochemical purity. In vitro experiments demonstrated high L-[123I]iodohistidine uptake by NSCLC cells, but in vivo studies confirmed that D-[123I]iodohistidine is a superior tumor imaging agent for SPECT/CT. Acknowledgements: This research was partially supported by NRF-2017M2A2A7A01071134, NRF-2015M2C2A1047687, and HI15C3093.

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Kim, H. Y., Lee, J. Y., Kim, Y. J., Lee, Y.-S., Jeong, J. M. Tags: Preclinical Probes for Oncology Posters Source Type: research