Laboratory characterisation of Salmonella enterica serotype Typhi isolates from Zimbabwe, 2009 –2017

Typhoid fever remains a major public health problem in Zimbabwe with recurrent outbreaks reported since 2009. To provide guidance on appropriate treatment choice in order to minimise the morbidity and mortalit...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research

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This study highlights the presence of potential genes as molecular targets to overcome the future endemic outbreaks in India. PMID: 31089918 [PubMed - as supplied by publisher]
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
We describe a ceftriaxone-resistant Salmonella Typhi bacteraemia in a pregnant woman returning from a family visit in Pakistan. Whole genome sequencing confirmed similarity to a Pakistani outbreak clone. Pregnancy and unawareness of this outbreak delayed appropriate antibiotic therapy. Concurrently, we detected faecal carriage of a carbapenemase-producing Escherichia coli. Awareness of the ongoing outbreak should affect empiric treatment of typhoid fever and hygiene precautions in travellers returning from Pakistan. Meropenem may be warranted in severe cases. PMID: 31138366 [PubMed - in process]
Source: Euro Surveill - Category: Infectious Diseases Authors: Tags: Euro Surveill Source Type: research
Conclusion: The falling number of salmonellosis cases in 2000⁻2017 in WaM reflects the general trend in Poland and Europe. The decrease of NTS infections in WaM is related to the accession of Poland into the EU. PMID: 30897848 [PubMed - in process]
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
Publication date: Available online 27 February 2019Source: PlasmidAuthor(s): Robert A. Moran, Isabella A. Richardson, Ruth M. HallAbstractTwo B/O plasmids were sequenced. The kanamycin resistance plasmid R805a was found in a Salmonella Typhi strain from a 1972 typhoid fever outbreak in Mexico City. pCERC6, which confers resistance to ampicillin, streptomycin and sulphamethoxazole, was found in a commensal E. coli isolated from a healthy adult in Sydney in 2008. Both plasmids contain the same gene for RNAI, the incompatibility determinant, as the reference B/O plasmid pMU707 and the recently reported plasmid p838B-R, which ...
Source: Plasmid - Category: Biotechnology Source Type: research
Recent cases of highly drug-resistant typhoid fever in returning travelers underscore the need for physicians to be aware of current global outbreaks, as well as their appropriate treatment.Morbidity &Mortality Weekly Report
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Public Health & Prevention Journal Article Source Type: news
Purpose: Background: Typhoid fever (TF) caused by Salmonella Typhi remains a major public health problem in Kenya. A systematic surveillance in two slum areas in Nairobi, revealed a crude incidence of TF of 247 cases per 100,000 person-years of observation (pyo), with highest rates in children 5 –9 years old (596 per 100,000pyo). Currently over a third of S. Typhi isolates are multidrug-resistant (MDR), and show reduced susceptibility to Fluoroquinolones; the drugs of choice for treatment of MDR cases.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 20.017 Source Type: research
We report on a three year-old male who contracted enteric fever during a visit to the Sindh province of Pakistan in the summer of 2018. He was diagnosed after returning to Canada and blood cultures isolated Salmonella enterica serovar Typhi which harbored extensive drug-resistance (XDR) to all first-line antibiotics including ceftriaxone. Empiric ceftriaxone was switched to meropenem and he was successfully treated with a two-week course. An outbreak of XDR typhoid is currently emerging from Pakistan and several outbreak-related cases have been identified in the U.K and U.S. Whole genome sequencing confirmed that our child...
Source: IDCases - Category: Infectious Diseases Source Type: research
Abstract In February 2018, a typhoid fever outbreak caused by Salmonella enterica serotype Typhi (Typhi), resistant to chloramphenicol, ampicillin, trimethoprim-sulfamethoxazole, fluoroquinolones, and third-generation cephalosporins, was reported in Pakistan. During November 2016-September 2017, 339 cases of this extensively drug-resistant (XDR) Typhi strain were reported in Pakistan, mostly in Karachi and Hyderabad; one travel-associated case was also reported from the United Kingdom (1). More cases have been detected in Karachi and Hyderabad as surveillance efforts have been strengthened, with recent reports inc...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
Imported, drug-resistant typhoid fever has been reported among travellers [1]. Typhoid fever is a highly contagious notifiable bacterial infection, spread by contaminated water and food. Each year, an estimated 26 million cases of typhoid fever appeared worldwide causing 215 thousand deaths. Multidrug resistance (MDR) is a foremost threat in Salmonella enterica serovar Typhi in parts of Asia and Africa. The first deadly outbreak of a novel S. Typhi H58 clone harboring resistance to three first-line drugs (ampicillin, chloramphenicol and co-trimoxazole) as well as the blaCTX-M-15 extended-spectrum β-lactamase and qnrS ...
Source: Travel Medicine and Infectious Disease - Category: Infectious Diseases Authors: Source Type: research
CONCLUSIONS: The transmission of ceftriaxone resistance from E. coli to S. Typhi is of concern because of clinical resistance to ceftriaxone, the main stay of typhoid treatment. Whole genome sequencing, albeit several years after the isolation, demonstrated the success of containment but clinical trials with alternative agents are urgently required. PMID: 29616895 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research
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