Range verification of radioactive ion beams of < sup > 11 < /sup > C and < sup > 15 < /sup > O using in-beam PET imaging.

Range verification of radioactive ion beams of ¹¹C and ¹⁵O using in-beam PET imaging.
Phys Med Biol. 2019 May 30;:
Authors: Mohammadi A, Tashima H, Iwao Y, Takyu S, Akamatsu G, Nishikido F, Yoshida E, Kitagawa A, Parodi K, Yamaya T
Abstract
In advanced ion therapy, the visualization of the range of incident ions in a patient's body is important for exploiting the advantages of this type of therapy. It is ideal to use radioactive ion beams for in-beam positron emission tomography (PET) imaging in particle therapy due to the high quality of PET images caused by the high signal-to-noise ratio. We have shown the feasibility of this idea through an in-beam PET study for 11C and 15O ion beams using the dedicated OpenPET system. In this work, we investigate the potential difference between the Bragg peak position and the position of the maximum detected positron-emitting fragments by a PET system for the radioactive beams of 11C and 15O. For this purpose, we measured the depth dose in a water phantom and performed PET scans of an irradiated PMMA phantom for the available beams of 11C and 15O at the Heavy Ion Medical Accelerator in Chiba (HIMAC). Then, we simulated the depth dose profiles in the water phantom and the yield of the positron-emitting fragments in a PMMA phantom for both available beams using the Monte Carlo code PHITS. The positions of the Bragg peak and maximum positron-emitting fr...

Source: Physics in Medicine and Biology - May 29, 2019 Category: Physics Authors: Mohammadi A, Tashima H, Iwao Y, Takyu S, Akamatsu G, Nishikido F, Yoshida E, Kitagawa A, Parodi K, Yamaya T Tags: Phys Med Biol Source Type: research