Virulence targeted inhibitory effect of linalool against the exclusive uropathogen Proteus mirabilis.

In this study, linalool exhibited concentration dependent anti-biofilm activity against crystalline biofilm of P. mirabilis through reduced production of the virulence enzyme urease that raises the urinary pH and drives the formation of crystals (struvite) in the biofilm. The results of q-PCR analysis unveiled the down regulation of biofilm/virulence associated genes upon linalool treatment, which was in correspondence with the in vitro bioassays. Thus, this study reports the feasibility of linalool acting as a promising anti-biofilm agent against P. mirabilis mediated CAUTI.
PMID: 31144520 [PubMed - as supplied by publisher]

Source: Biofouling - May 29, 2019 Category: Molecular Biology Authors: Durgadevi R, Veera Ravi A, Alexpandi R, Krishnan Swetha T, Abirami G, Vishnu S, Karutha Pandian S Tags: Biofouling Source Type: research