HEAL Initiative: Translational Development of Devices to Treat Pain (U18 Clinical Trial Not Allowed)

The purpose of this Funding Opportunity Announcement (FOA) is to support preclinical development and demonstration of safe, effective, and non-addictive device-based technologies and approaches to treat pain. The goal of the program is to demonstrate treatment using credible neural targets for device-based interventions and/or diagnostics for pain, building upon the latest mechanistic knowledge about the anatomy and physiology of central, spinal, and peripheral pathways involved in pain. Awarded activities will facilitate the translation of new devices up to the stage of readiness for first in human (FIH) clinical trials by overcoming key challenges identified during preliminary proof-of-concept studies. The scope of the program includes technology development and optimization, and studies to prepare for approvals for human use. This is a milestone-driven cooperative agreement program and will involve participation of NIH program staff in the development of the project plan and monitoring of research progress.Teresa Jones, M.D. | RFA-EB-18-003
Source: NIDDK Funding Opportunities - Category: Endocrinology Source Type: funding

Related Links:

The United States opioid epidemic is a well-documented crisis stemming from increased prescription of narcotics, leading to widespread misuse of both prescription and nonprescription opioid pain relievers. To combat this epidemic, online prescription drug monitoring programs (PDMPs) have been implemented at the state level to track prescriptions of controlled substances and mitigate potential misuse and addiction.
Source: The Spine Journal - Category: Orthopaedics Authors: Source Type: research
Rheumatol Ther. 2021 Jul 30. doi: 10.1007/s40744-021-00350-8. Online ahead of print.ABSTRACTAcute and chronic pain are public health issues that clinicians have been battling for years. Opioid medications have been a treatment option for both chronic and acute pain; however, they can cause unwanted complications and are a major contributor to our present opioid epidemic. The sacroiliac (SI) joint is a common cause of both acute and chronic low back pain. It affects about 15-25% of patients with axial low back pain, and up to 40% of patients with ongoing pain following lumbar fusion. Recent advances in the treatment of SI j...
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
Jackson Avenue is the main road that cuts through Oxford, Miss. At its northern limit, it circles the Ole Miss campus where Raven Saunders had spent the past three years as a student athlete. At its western end, Jackson splits into a T junction populated by a cluster of familiar American fast food restaurants and retail chains: a Walmart Supercenter, a Home Depot, a Popeye’s, a Chick-Fil-A. Saunders, a senior at University of Mississippi and a star shot putter on the school’s track and field team, knew the intersection well. Turn right, and the road led home. Turn left, and the highway hugged a steep drop-off f...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized olympics Tokyo Olympics Source Type: news
This article reviews the evidence for the treatment of painful-DPN, including emerging treatment strategies, such as novel compounds and stratification of patients according to individual characteristics, (e.g., pain phenotype, neuroimaging, and genotype) to improve treatment responses.PMID:34238163 | DOI:10.2174/1573399817666210707112413
Source: Current Diabetes Reviews - Category: Endocrinology Authors: Source Type: research
Conclusions: Research results suggest that the pandemic is negatively affecting students. Frequent occurrence of back pain is observed with a simultaneous low level of physical activity. Maintaining regular activity during a pandemic, at least at home, is an indispensable preventive measure for physical health.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
It’s no secret that technology has had a monumental impact on our society and our daily lives in an incredibly short amount of time. Google is only 22 years old, Youtube is 16 years old, and Facebook is about 17 years old. Some people may fondly remember simpler times before these tech giants came about, while other people simply cannot imagine life without them. Either way, it’s obvious that our reliance on technology isn’t going anywhere, so it’s important to know how to be able to tell when it’s time to take a break from your electronic devices. Mental Health Decline If you are experi...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: depression featured internet culture psychology self-improvement success working from home digital detox mental health pickthebrain technology Source Type: blogs
ConclusionDespite being turned back from an effort to bluntly reduce opioid prescribing by the FDA in 2013 based on a lack of scientific evidence for its position (17,18), PROP has had a disproportionate effect on opioid policy in the Untied States for almost a decade. PROP found a willing federal regulatory partner in the CDC, and while PROP may not have “secretly written” the 2016 CDC Pain Guidelines (75), they certainly enjoyed disproportionate representation on CDC’s review panels and Core Expert Group (23-25) in a process that lacked transparency (22, 23, 26, 27). When the CDC admitted that its Pain ...
Source: Pallimed: A Hospice and Palliative Medicine Blog - Category: Palliative Care Tags: CDC health policy kollas opioids pain prop Source Type: blogs
Conclusions: After a visit to a PCP for a new episode of care for LBP, patients with a history of an OUD are less likely to initiate physical therapy.
Source: Journal of Addiction Medicine - Category: Addiction Tags: Original Research Source Type: research
Conclusion This is an unusual fascinating case which posed a significant diagnostic dilemma. Ruling out infection particularly in great challenge in diagnosing CRMO in a male adult who is homeless and a heroin abuser presenting with multifocal osteolytic lesions was challenging. The severity of his conditio n necessitated using novel treatments such as tocilizumab.Disclosure W. Ng: None.A. Anjum: None.J. Devlin: None.A. Fraser: None.
Source: Rheumatology - Category: Rheumatology Source Type: research
By HANS DUVEFELT A “frozen shoulder” can be manipulated to move freely again under general anesthesia. The medications we use to put patients to sleep for such procedures work on the brain and don’t concentrate in the shoulder joints at all. An ingrown toenail can be removed or an arthritic knee can be replaced by injecting a local anesthetic – at the base of the toe or into the spine – interrupting the connection between the body and the brain. An arthritic knuckle can stop hurting and move more freely after a steroid injection that dramatically reduces inflammation, giving lasting r...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Medical Practice Patients Physicians Primary Care Hans Duvefelt Pain Management Source Type: blogs
More News: Addiction | Anatomy | Back Pain | Clinical Trials | Endocrinology | Funding | Pain | Physiology | Study