Assessment of treatment impact on lymphatic filariasis in 13 districts of Benin: progress toward elimination in nine districts despite persistence of transmission in some areas

Lymphatic filariasis (LF) is still a public health burden in many developing countries. In Benin, a West African country, at least 6.6 million people are at risk for LF. With the goal of eliminating LF by 2020...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research

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by Carmen Maroto-Camino, Pilar Hernandez-Pastor, Naomi Awaca, Lebon Safari, Janet Hemingway, Marilia Massangaie, Donald Whitson, Caroline Jeffery, Joseph J. Valadez Lymphatic filariasis (LF) elimination as a public health problem requires the interruption of transmission by administration of preventive mass drug administration (MDA) to the eligible population living in endemic districts. Suboptimal MDA coverage leads to persistent parasite transmission with c onsequential infection, disease and disability, and the need for continuing MDA rounds, requiring considerable investment. Routine coverage reports must be verified ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
CONCLUSION: Flowers of C. procera have definite microfilaricidal and macrofilaricidal activity. Whether this activity is due to lupeol, β-sitosterol and triacontanol found in the hexane fraction remains to be investigated. This is the first report on antifilarial efficacy of flowers of the plant C. procera. PMID: 31218959 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research
CONCLUSION: The present study suggests that 3-O-acyl and linear chain amide derivatives of glycyrrhetinic acid may be potent leads against B. malayi microfilariae and adult worms. These results may be of great help in developing QSAR model for optimizing a new class of antifilarial lead from a very common, inexpensive, and non toxic natural product. PMID: 31210109 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research
Abstract Lymphatic filariasis is a mosquito-borne parasitic disease responsible for morbidity and disability that affects 1.2 billion people worldwide, mainly the poor communities. Currently, filarial antigen testing is the method of choice for the detection of bancroftian filariasis, and to date, there are two commonly used tests. In the present study, a recently reported recombinant monoclonal antibody (5B) specific to BmSXP filarial antigen was used in developing an ELISA for the detection of circulating filarial antigen in sera of patients with bancroftian filariasis. The performance of the ELISA was evaluated...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
AbstractBrugian filariasis is reported in dogs in Kerala, India. Antibody detection kits are not available worldwide, for detection of Brugian filariasis in dogs. A study was carried out to develop Indirect plate ELISA using excretory secretory antigen isolated from canine brugian microfilariae and compare the sensitivity and specificity with that of blood smear examination. Identification of microfilariae was done by acid phosphatase staining using Naphthol AS-TR method and Polymerase Chain Reaction forHha 1 repeat sequence. The microfilariae were identified asBrugia malayi. Isolation of brugian microfilariae from canine ...
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
ConclusionsMalaria and LF transmission appear absent or extremely low in Dominicanbateyes, which are a mixture of Haitian and Dominican residents. Travel to Haiti is rare, meaning risk of malaria and LF importation is low. Addressing identified gaps in intervention coverage, malaria knowledge, treatment seeking and service delivery will improve the quality of surveillance for these diseases, particularly among marginalized populations and promote island-wide elimination.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
Lymphatic Filariasis (LF) is a vector-borne neglected tropical disease caused by the filarial nematode parasites that can lead to the disfiguring swelling of the limbs (lymphedema or elephantiasis for late sta...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
Lymphatic filariasis (LF) is a mosquito-borne parasitic disease and a major cause of disability worldwide. To effectively plan morbidity management programmes, it is important to estimate disease burden and ev...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
Jeffrey G. Shaffer1*, Frances J. Mather1, Mamadou Wele2, Jian Li1, Cheick Oumar Tangara2, Yaya Kassogue2, Sudesh K. Srivastav1, Oumar Thiero2, Mahamadou Diakite2, Modibo Sangare2, Djeneba Dabitao2, Mahamoudou Toure2, Abdoulaye A. Djimde2, Sekou Traore2, Brehima Diakite2, Mamadou B. Coulibaly2, Yaozhong Liu1, Michelle Lacey3, John J. Lefante1, Ousmane Koita2, John S. Schieffelin4, Donald J. Krogstad1 and Seydou O. Doumbia2 1Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States 2Faculty of Medicine and Odontostomatology, Un...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Little is known regarding risk factors for lymphatic filariasis (LF) in Central Africa. To expand on what is known, we studied the epidemiology of LF in two endemic villages in the Democratic Republic of the C...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
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