Interleukin-1beta Inhibition Attenuates Vasculitis in a Mouse Model of Kawasaki Disease.

CONCLUSIONS: The anti-IL-1β antibody significantly attenuated CAWS-induced vasculitis. The mechanism of inhibiting vasculitis is thought to include inhibition of the IL-1β pathway and additional effects beyond blocking IL-1β signaling.
PMID: 31130561 [PubMed - in process]

Source: Journal of Nippon Medical School - May 30, 2019 Category: Universities & Medical Training Authors: Hashimoto Y, Fukazawa R, Nagi-Miura N, Ohno N, Suzuki N, Katsube Y, Kamisago M, Akao M, Watanabe M, Hashimoto K, Tsuno K, Matsui R, Itoh Y Tags: J Nippon Med Sch Source Type: research