Is immunohistochemistry-based screening for Lynch syndrome in endometrial cancer effective? The consent's the thing.

CONCLUSION: The primary driver of failure to identify index cases remains consent for sequencing. Consent rates have shown little improvement since LS screening programs were instituted in the U.S., leaving us to conclude these high failure rates are resistant to substantial improvement. These missed opportunities will be magnified because cascade screening for carrier status among family members will not be pursued. PMID: 31130287 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31130287?dopt=Abstract

Source: Gynecologic Oncology - May 22, 2019 Category: Cancer & Oncology Authors: Gudgeon JM, Varner MW, Hashibe M, Williams MS Tags: Gynecol Oncol Source Type: research