Effects of asiatic acid, an active constituent in Centella asiatica (L.): restorative perspectives of streptozotocin-nicotinamide induced changes on lipid profile and lipid metabolic enzymes in diabetic rats

AbstractThe present study was aimed to evaluate the restorative efficacy of asiatic acid (AA), an active constituent inCentella asiatica (L.) in streptozotocin (STZ)-nicotinamide (NAD)-induced diabetic rats. Male Wistar albino rats were made diabetic with STZ-NAD administration and assessed the effect of AA (20, 30, and 40  mg/kg body weight per day, for 45 days) on body weight, glucose, insulin, insulin resistance, lipid metabolic parameters in plasma and tissue (liver and kidney), and histopathology of liver in control and experimental diabetic rats. A significant (p 
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Publication date: Available online 12 November 2019Source: Life SciencesAuthor(s): Younis Ahmad Hajam, Seema RaiAbstractAimsThe present study was designed to ameliorate the integrated efficacy of exogenous melatonin and insulin on tissue biochemical, serological, histopathological architecture and receptor expression of melatonin (MT1, MT2) and insulin receptor (IR) expression against the hepatic injury in diabetic rats. Materials and Method; the rats were randomly allocated into nine different experimental groups. Diabetes was induced by streptozotocin (15mg/kg) for 6 days. Rats having blood glucose level above 250mg/dl w...
Source: Life Sciences - Category: Biology Source Type: research
ConclusionLV mass and diastolic function were not affected after 1  year of metformin treatment in patients with T2DM. However, we observed benefits in terms of reductions in both BMI and LDL-C levels and preservation of renal function.Trial RegistrationUMIN000006504. Registered 7 October 2011.
Source: American Journal of Cardiovascular Drugs - Category: Cardiology Source Type: research
ConclusionsIn this high-risk low-income cohort, contributions of risk factors to HF varied, particularly by race. To reduce the population burden of HF, interventions tailored for specific race and sex groups may be warranted.Graphical abstract
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
In recent years, epidemiologists have found that waist circumference is a better measure of the burden of excess visceral fat tissue than body mass index (BMI). Progress towards making better use of this information has been slow, as is usually the case in the world of epidemiology. Visceral fat tissue generates chronic inflammation through a variety of mechanisms, from DNA debris activating the immune system to inappropriate signaling by fat cells to an accelerated pace of generation of senescent cells. Chronic inflammation disrupts function and accelerates the progression of all of the common age-related conditions. Peop...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Consuming a high-fat diet (HFD) is a risk factor for obesity and diabetes; both of these diseases are also associated with systemic inflammation, similar to HIV infection. A HFD induces intestinal dysbiosis and impairs liver function and coagulation, with a potential negative impact on HIV/SIV pathogenesis. We administered a HFD rich in saturated fats and cholesterol to nonpathogenic (African green monkeys) and pathogenic (pigtailed macaques) SIV hosts. The HFD had a negative impact on SIV disease progression in both species. Thus, increased cell-associated SIV DNA and RNA occurred in the HFD-receiving nonhuman primates, i...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
We read with great interest the recent article by Nunes and Pretorius [1] showing that individuals with type II diabetes exhibit elevated erythrocyte membrane cholesterol levels which may act as a prominent link between the diabetic state and subsequent cardiovascular complications. The study results are intriguing and elucidate further the research hypothesis of the detrimental pathophysiological role of erythrocyte membranes and especially membrane lipids in variety of cardiovascular disorders [2,3].
Source: Thrombosis Research - Category: Hematology Authors: Tags: Letter to the Editors-in-Chief Source Type: research
Neither vitamin D3 nor omega-3 fatty acid supplements cut CKD risk in people with type 2 diabetes over five years Related items fromOnMedica UK research reveals racial inequalities in diabetes care Statins of small and uncertain benefit in primary prevention Should we recognise obesity as a disease? Sugar not saturated fat is the major issue for CVD WHO dietary fat guidance fails to consider crucial evidence
Source: OnMedica Latest News - Category: UK Health Source Type: news
Switch from target-based to risk-based approach seems to have improved cholesterol – notably in those taking statins Related items fromOnMedica UK research reveals racial inequalities in diabetes care Statins of small and uncertain benefit in primary prevention Pharmacists could offer high-dose statins direct to patients WHO dietary fat guidance fails to consider crucial evidence Vitamin D supplements do not confer cardiovascular protection
Source: OnMedica Latest News - Category: UK Health Source Type: news
A 40-year-old man was treated with tonsillectomy and underwent early surgical exploration because of bleeding. Postoperative bleeding complications were treated with bronchoscopy. In addition to obesity, normal thyroid function, type 2 diabetes mellitus, and current tobacco abuse with severe obstructive sleep apnea syndrome, biochemistry revealed severe hypercholesterolemia (total cholesterol 572 mg/dL) and hypertriglyceridemia (1,220 mg/dL). During the postoperative period, low doses of propofol (up to 2 mg/kg/h for 10 hours), along with remifentanil (up to 0.0016 mg/kg/h for 20 hours), midazolam, and tramadol, were neede...
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Letter to the Editor Source Type: research
CONCLUSION: Dyslipidemia patients with pre-existing depression had increased risk for CVD. Future studies that determine CVD risk after management of depression among dyslipidemia patients are needed. PMID: 31701694 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
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