Causes and consequences of cardiac fibrosis in patients referred for surgical aortic valve replacement

ConclusionsWe found a positive correlation between elevated inflammatory markers and degree of fibrosis load. These two parameters were associated with worse outcomes in patients with severe AS. Our results may be of interest especially in patients for whom a transcatheter aortic valve implantation is indicated and myocardial biopsy is not possible. Strategies aiming at preventing inflammation might be considered to decrease or limit the progression of cardiac fibrosis in patients followed for AS.

Source: ESC Heart Failure - May 20, 2019 Category: Cardiology Authors: Arnault Galat, Aziz Guellich, Diane Bodez, Larissa Lipskaia, St éphane Moutereau, Eric Bergoend, Sophie Hüe, Julien Ternacle, Dania Mohty, Jean‐Luc Monin, Geneviève Derumeaux, Costin Radu, Thibaud Damy Tags: Original Research Article Source Type: research