Waiting Impulsivity During Reward Seeking Increases Adult Hippocampal Neurogenesis in Mice

Publication date: Available online 19 May 2019Source: Neuroscience LettersAuthor(s): Lee Peyton, Alfredo Oliveros, Chang Hoon Cho, Phillip Starski, Daniel Lindberg, Mi-Hyeon Jang, Doo-Sup ChoiAbstractImpulsivity is defined as a predisposition toward rapid, unplanned reactions in response to internal or external stimuli, often yielding negative consequences. Accordingly, impulsivity is considered a significant risk factor for developing addictive behaviors. The hippocampus is involved in regulating behavioral adaptability and learned behaviors. Consequently, abnormal hippocampal function has been demonstrated to contribute to impulsive and addictive behaviors. Furthermore, differential reinforcement of low rates of behavior (DRL) has shown that the hippocampus is implicated in reward acquisition and impulsivity in humans and rodent models. We have previously shown that impulsive behavior potentiates hippocampal neuroblast proliferation. However, the fate of these precursor cells produced during impulsive reward seeking remains unknown. Here, we demonstrate that DRL-mediated impulsive reward seeking with the 2-choice reaction time task (2-CRTT) increases the number of BrdU labeled cells in the dentate gyrus region of the hippocampus. Importantly, our results also show a significant increase in BrdU+ and NeuN+ colocalized mature newborn neurons in mice exhibiting impulsivity compared to non-impulsive control mice. These results suggest that operant reward seeking during unpredic...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research

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Publication date: Available online 23 June 2019Source: Redox BiologyAuthor(s): Diego G. Ogando, Moonjung Choi, Rajalekshmy Shyam, Shimin Li, Joseph A. BonannoAbstractSLC4A11 is a NH3 sensitive membrane transporter with H+ channel-like properties that facilitates Glutamine catabolism in Human and Mouse corneal endothelium (CE). Loss of SLC4A11 activity induces oxidative stress and cell death, resulting in Congenital Hereditary Endothelial Dystrophy (CHED) with corneal edema and vision loss. However, the mechanism by which SLC4A11 prevents ROS production and protects CE is unknown. Here we demonstrate that SLC4A11 is localiz...
Source: Redox Biology - Category: Biology Source Type: research
E-cigarettes and tobacco products contain an addictive drug called nicotine, which makes it very hard to stop using them.Read  More »
Source: NIDA Drugs and Health Blog - Category: Addiction Source Type: blogs
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Jack Richie started gambling at school and took his own life at 24. His parents say the addiction is 'not unlike a heroin addiction'.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
The first National Problem Gambling Clinic, offering support to people aged 13 to 25, is set to open.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Conclusion: The concomitant use of nicotine and areca indicates that betel quid addiction includes a significant component of nicotine dependence. However, the additional activities of areca, including the muscarinic effects of arecoline, indicate that potential cessation therapies should optimally address other factors as well. PMID: 31220988 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
How Do I Pick the Right Facility for My Addiction? Finally making the decision to get help for your addiction is a huge, difficult step. Admitting you have a problem and expressing the desire to want to fix it is life-saving. Almost as difficult as making the decision to go to a facility is trying to pick the right facility. There are so many factors to consider, and finding the right facility can make all the difference in your long-term sobriety and recovery. As you do your research, we’ve compiled the most important points for you to keep in mind. Staff and Accreditations at the Facility When you are picking a fac...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction Recovery Addiction Treatment and Program Resources Behavioral Addictions Complementary Therapies Comprehensive behavioral treatment Drug Rehab Information Holistic Treatment Protocols Sober Living and Aftercare Substa Source Type: blogs
This Tuesday, the San Francisco Board of Supervisors is scheduled to vote on a proposed ordinance that would ban the sale of cigarettes and marijuana products in the city until the FDA conducts a safety review of these products.The impetus for the proposed ordinance was new data showing that a large proportion of San Francisco youths are still smoking and that the use of marijuana may even be increasing, especially with the recent legalization of recreational marijuana use. The city attorney explained that: " The epidemic is real. It needed attention. We felt it was necessary to step in and make sure we were protectin...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - Category: Addiction Source Type: blogs
Nancy Labov's nonprofit gives young adults in recovery a platform at local schools.
Source: AJN - Category: Nursing Tags: Profiles Source Type: research
Authors: Fischer B, Casswell S Abstract The New Zealand Government Inquiry Into Mental Health And Addiction recently tabled its final report, including a substantial set of recommendations. Four of these recommendations focused specifically on interventions and policy for psychoactive substance use (including alcohol and drugs). Based on longstanding involvement in science on alcohol- and other drugs-related health and policy, and similar commission efforts, the authors briefly examine and provide comments on these recommendations from a scientific evidence perspective. In sum, the Inquiry's recommendations provide...
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
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