High-intensity interval exercise lowers postprandial glucose concentrations more in obese adults than lean adults

Obesity is usually accompanied with endothelial dysfunction and insulin resistance, potentially actuating early pathogenesis of type 2 diabetes (T2D) and cardiovascular disease (CVD) [1]. Compared to normal-weight individuals, obese individuals may exhibit metabolic defects in insulin-sensitive tissues, and reduced glucose uptake and utilization capacity [2,3]. Thus, obese people more commonly exhibit glucose and insulin homoeostasis abnormalities, and have a higher diabetes risk. An amplified blood glucose increase after eating, termed postprandial hyperglycaemia, prompts excessive free radical production that acutely triggers atherogenic changes —including pro-inflammatory conditions, hypercoagulability, and endothelial dysfunction [4]—contributing to CVD evolution [5,6].

Source: Primary Care Diabetes - May 16, 2019 Category: Primary Care Authors: Zhaowei Kong, Qingde Shi, Shengyan Sun, Tomas K. Tong, Haifeng Zhang, Jinlei Nie Tags: Original research Source Type: research