Nonhuman leukocyte antigen antibodies that have impact in the heart transplant patient.

Nonhuman leukocyte antigen antibodies that have impact in the heart transplant patient.
Curr Opin Organ Transplant. 2019 Jun;24(3):279-285
Authors: Reddy YNV, Pereira NL
Abstract
PURPOSE OF REVIEW: Despite human leukocyte antigen (HLA) matching and monitoring for donor-specific HLA antibodies, antibody-mediated rejection and chronic rejection in the form of allograft vasculopathy and chronic graft dysfunction continue to occur. There has been increasing interest in non-HLA antibodies as mediators of these changes.
RECENT FINDINGS: In this review, we discuss the recent literature describing the importance of non-HLA antibodies in organ transplantation and summarize the literature evaluating such antibodies in heart transplantation.
SUMMARY: Monitoring of non-HLA antibodies requires additional measurement standardization and correlation of specific antibodies with outcomes. However, there is promise that identification with newer immunoproteomic techniques and therapy toward such antibodies may improve long-term graft outcomes and decrease acute rejection and allograft vasculopathy.
PMID: 31090636 [PubMed - in process]

Source: Current Opinion in Organ Transplantation - May 17, 2019 Category: Transplant Surgery Authors: Reddy YNV, Pereira NL Tags: Curr Opin Organ Transplant Source Type: research